@article{rimbach_dietary_2008, title = {Dietary isoflavones in the prevention of cardiovascular disease-a molecular perspective}, author = {Gerald Rimbach and Christine Boesch-Saadatmandi and Jan Frank and Dagmar Fuchs and Uwe Wenzel and Hannelore Daniel and Wendy L Hall and Peter D Weinberg}, journal = {Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association}, pages = {1308-19}, volume = {46}, year = {2008}, biburl = {http://www.bibsonomy.org/bibtex/2d3f2a6e6b5dd285120ecd8589769c4f3/molnutrition}, abstract = {The Food and Drugs Administration has approved a health claim for soy based on clinical trials and epidemiological data indicating that high soy consumption is associated with a lower risk of coronary artery disease. Soy products contain a group of compounds called isoflavones, with genistein and daidzein being the most abundant. A number of cardioprotective benefits have been attributed to dietary isoflavones including a reduction in LDL cholesterol, an inhibition of pro-inflammatory cytokines, cell adhesion proteins and inducible nitric oxide production, potential reduction in the susceptibility of the LDL particle to oxidation, inhibition of platelet aggregation and an improvement in vascular reactivity. There is increasing interest in the use of nutrigenomic methods to understand the mechanisms by which isoflavones induce these changes, and in the use of nutrigenetics to understand why the effects vary between individuals. Nutrigenomics is a rapidly growing field making use of molecular biology methodologies, such as microarray technology and proteomics, to study how specific nutrients or diets affect gene expression and cellular protein levels. The analysis of differential gene expression and protein levels in endothelial cells, macrophages and smooth muscle cells is critical to elucidating the sequence of events leading to the formation of atherosclerotic lesions, and to understanding the potential anti-atherogenic properties of soy isoflavones. An increasing number of studies demonstrate a significant impact of genetic variation on changes in cardiovascular risk factors in response to dietary intervention. Nutrigenetic effects of this type have recently been reported for dietary isoflavones, and may help to explain some of the disparities in the current literature concerning isoflavones and cardiovascular health.}, issn = {02786915}, keywords = {IFZ imported } } @article{fuchs_proteome_2007, title = {Proteome analysis suggests that mitochondrial dysfunction in stressed endothelial cells is reversed by a soy extract and isolated isoflavones}, author = {Dagmar Fuchs and Barbara Dirscherl and Joyce H Schroot and Hannelore Daniel and Uwe Wenzel}, journal = {Journal of proteome research}, pages = {2132-42}, volume = {6}, year = {2007}, biburl = {http://www.bibsonomy.org/bibtex/2eecdfce895746a0e03e751a0d961a54d/molnutrition}, abstract = {Apoptosis is a driving force in atherosclerosis development. A soy extract or a combination of the soy isoflavones genistein and daidzein inhibited apoptosis induced by oxidized LDL in endothelial cells. Proteome analysis revealed that the LDL-induced alterations of numerous proteins were reversed by the extract and the genistein/daidzein mixture but only three protein entities, all functionally linked to mitochondrial dysfunction, were regulated in common by both treatments.}, issn = {15353893}, keywords = {Apoptosis Endothelial_Cells Endothelium Genistein Humans IFZ Isoflavones LDL Lipoproteins Mass Matrix-Assisted_Laser_Desorption-Ionization Mitochondria Oxidation-Reduction Plant_Extracts Proteome Soybeans Spectrometry Vascular } } @article{fuchs_proteomic_2007, title = {Proteomic biomarkers of peripheral blood mononuclear cells obtained from postmenopausal women undergoing an intervention with soy isoflavones}, author = {Dagmar Fuchs and Katerina Vafeiadou and Wendy L Hall and Hannelore Daniel and Christine M Williams and Joyce H Schroot and Uwe Wenzel}, journal = {The American journal of clinical nutrition}, pages = {1369-75}, volume = {86}, year = {2007}, biburl = {http://www.bibsonomy.org/bibtex/263b8fb5f3537b30feda3319cbc466675/molnutrition}, abstract = {BACKGROUND: The incidence of cardiovascular diseases increases after menopause, and soy consumption is suggested to inhibit disease development. OBJECTIVE: The objective was to identify biomarkers of response to a dietary supplementation with an isoflavone extract in postmenopausal women by proteome analysis of peripheral blood mononuclear cells. DESIGN: The study with healthy postmenopausal woman was performed in a placebo-controlled sequential design. Peripheral mononuclear blood cells were collected from 10 volunteers after 8 wk of receiving daily 2 placebo cereal bars and after a subsequent 8 wk of intervention with 2 cereal bars each providing 25 mg of isoflavones. The proteome of the cells was visualized after 2-dimensional gel electrophoresis, and peptide mass fingerprinting served to identify proteins that by the intervention displayed altered protein concentrations. RESULTS: Twenty-nine proteins were identified that showed significantly altered expression in the mononuclear blood cells under the soy-isoflavone intervention, including a variety of proteins involved in an antiinflammatory response. Heat shock protein 70 or a lymphocyte-specific protein phosphatase and proteins that promote increased fibrinolysis, such as alpha-enolase, were found at increased intensities, whereas those that mediate adhesion, migration, and proliferation of vascular smooth muscle cells, such as galectin-1, were found at reduced intensities after soy extract consumption. CONCLUSION: Proteome analysis identified in vivo markers that respond to a dietary intervention with isoflavone-enriched soy extract in postmenopausal women. The nature of the proteins identified suggests that soy isoflavones may increase the antiinflammatory response in blood mononuclear cells that might contribute to the atherosclerosis-preventive activities of a soy-rich diet.}, issn = {00029165}, keywords = {Aged Biological_Markers Blood_Proteins Female HSP70_Heat-Shock_Proteins Humans IFZ Isoflavones Leukocytes Middle_Aged Mononuclear Postmenopause Proteomics Soybeans } } @article{fuchs_human_2007, title = {The human peripheral blood mononuclear cell proteome responds to a dietary flaxseed-intervention and proteins identified suggest a protective effect in atherosclerosis}, author = {Dagmar Fuchs and Regina Piller and Jakob Linseisen and Hannelore Daniel and Uwe Wenzel}, journal = {Proteomics}, pages = {3278-88}, volume = {7}, year = {2007}, biburl = {http://www.bibsonomy.org/bibtex/21fa08761d907b192469875243c34d12b/molnutrition}, abstract = {Flaxseed is one of the richest sources of lignans that are converted to enterolactone by the intestinal microflora. Enterolactone has been suggested to be the prime active compound mediating atherosclerosis-protective effects that were shown for flaxseed. The effects of a 1-wk intervention with 0.4 g of flaxseed/kg body weight per day on enterolactone plasma levels in seven healthy men revealed that all participants (PAs) responded with enhanced enterolactone plasma levels. Proteome analysis of peripheral blood mononuclear cells (PBMC) from donors before, during, and after the intervention showed that flaxseed consumption affected significantly the steady-state levels of 16 proteins of which four were altered in a similar manner when blood mononuclear cells were exposed ex vivo to enterolactone. Enhanced levels of peroxiredoxin and reduced levels of the long-chain fatty acid beta-oxidation multienzyme complex may be taken as indicators of a reduced oxidative stress whereas reduced levels of glycoprotein IIIa/II could indicate improved protection from thrombotic and inflammatory processes. In conclusion, the blood mononuclear cell proteome responds to dietary flaxseed intake with changes in a number of atherosclerosis-relevant proteins that may be taken as biomarkers of exposure and some of these changes observed can be attributed to the action of the lignan metabolite enterolactone.}, issn = {16159853}, keywords = {4-Butyrolactone Adult Atherosclerosis Blood_Proteins Diet Electrophoresis Flax Gel Humans IFZ Lignans Male Mass Matrix-Assisted_Laser_Desorption-Ionization Peptide_Mapping Proteome Spectrometry Two-Dimensional } } @inproceedings{conf/dsd/BeckertFRH07, title = {A Run-Time Scheduling Framework for a Reconfigurable Hardware Emulator.}, author = {Rene Beckert and Thomas Fuchs and Steffen Rülke and Wolfram Hardt}, booktitle = {DSD}, crossref = {conf/dsd/2007}, pages = {147-150}, publisher = {IEEE}, url = {http://dblp.uni-trier.de/db/conf/dsd/dsd2007.html#BeckertFRH07}, year = {2007}, biburl = {http://www.bibsonomy.org/bibtex/2954cbbf9482da1e187001bc126d07e7e/dblp}, description = {dblp}, ee = {http://dx.doi.org/10.1109/DSD.2007.4341462}, date = {2008-07-09}, keywords = {dblp } } @article{Fuchs07InformatikSpektrum, title = {{SAP NetWeaver in der Praxis -- Wie gut bewährt sich der Technologie-Stack in der praktischen Arbeit?}}, author = {Stefan K. Fuchs}, journal = {Informatik-Spektrum}, number = {6}, pages = {428-433}, url = {http://dx.doi.org/10.1007/s00287-007-0191-3}, volume = {30}, year = {2007}, biburl = {http://www.bibsonomy.org/bibtex/27c78e338454745744f38d6d06325d879/flint63}, abstract = {SAP NetWeaver ist eine Zusammenführung von bereits bewährten und neuen technischen Komponenten von SAP zur Realisierung von Integrationsprojekten auf unterschiedlichster Ebene. Dieser Artikel zeigt auf, dass sich unserer Meinung nach NetWeaver erst am Beginn eines breiteren Einsatzes befindet.}, issn = {0170-6012}, timestamp = {2008.02.05}, file = {SpringerLink:2007/Fuchs07InformatikSpektrum.pdf:PDF}, owner = {flint}, keywords = {application enterprise middleware paper sap server software springer v0805 } } @inproceedings{conf/dagm/FuchsLWMB08, title = {Weakly Supervised Cell Nuclei Detection and Segmentation on Tissue Microarrays of Renal Clear Cell Carcinoma.}, author = {Thomas J. Fuchs and Tilman Lange and Peter J. Wild and Holger Moch and Joachim M. Buhmann}, booktitle = {DAGM-Symposium}, crossref = {conf/dagm/2008}, editor = {Gerhard Rigoll}, pages = {173-182}, publisher = {Springer}, series = {Lecture Notes in Computer Science}, url = {http://dblp.uni-trier.de/db/conf/dagm/dagm2008.html#FuchsLWMB08}, volume = {5096}, year = {2008}, biburl = {http://www.bibsonomy.org/bibtex/24f5dc24d3f8658fb8c27ccb4136f9e85/dblp}, description = {dblp}, date = {2008-07-03}, ee = {http://dx.doi.org/10.1007/978-3-540-69321-5_18}, isbn = {978-3-540-69320-8}, keywords = {dblp } } @inproceedings{conf/vr/JohnsonGSTF07, title = {A Personal Surround Environment: Projective Display with Correction for Display Surface Geometry and Extreme Lens Distortion.}, author = {Tyler Johnson and Florian Gyarfas and Rick Skarbez and Herman Towles and Henry Fuchs}, booktitle = {VR}, crossref = {conf/vr/2007}, editor = {William R. Sherman and Ming Lin and Anthony Steed}, pages = {147-154}, publisher = {IEEE Computer Society}, url = {http://dblp.uni-trier.de/db/conf/vr/vr2007.html#JohnsonGSTF07}, year = {2007}, biburl = {http://www.bibsonomy.org/bibtex/2f8c5d052fe734a469bd8d77f6e8867d6/dblp}, description = {dblp}, date = {2008-06-24}, ee = {http://doi.ieeecomputersociety.org/10.1109/VR.2007.352475}, isbn = {1-4244-0905-5}, keywords = {dblp } } @inproceedings{conf/vr/BurdeaCFS07, title = {VR Support of Clinical Applications: Collaboration, Politics, and Ethics.}, author = {Grigore C. Burdea and Zohara A. Cohen and Henry Fuchs and Richard M. Satava}, booktitle = {VR}, crossref = {conf/vr/2007}, editor = {William R. Sherman and Ming Lin and Anthony Steed}, pages = {311-312}, publisher = {IEEE Computer Society}, url = {http://dblp.uni-trier.de/db/conf/vr/vr2007.html#BurdeaCFS07}, year = {2007}, biburl = {http://www.bibsonomy.org/bibtex/22491a7dba5d261740c26dce37f69eb48/dblp}, description = {dblp}, isbn = {1-4244-0905-5}, date = {2008-06-24}, keywords = {dblp } } @article{0741-3335-40-1-004, title = {Vector and scalar tomography on fusion plasmas using Hamiltonian and variational methods}, author = {G Fuchs and V Pickalov}, journal = {Plasma Physics and Controlled Fusion}, number = {1}, pages = {91-96}, url = {http://stacks.iop.org/0741-3335/40/91}, volume = {40}, year = {1998}, biburl = {http://www.bibsonomy.org/bibtex/2d68ebac6901e643828de63c6a185933c/pick600}, abstract = {A method is presented to obtain tomographic inversions of line-integrated measurements in magnetized plasmas, both for the cases of scalar and vector fields. For the Hamiltonian flow of the magnetic field in tokamaks the vector tomographic problem can be reduced to a scalar one. In many fusion experiments the amount of measured data is insufficient to allow an inversion without further assumptions. We present a variational method, where such assumptions can easily be implemented by the use of constraints. We outline the procedures using the example of obtaining the function on tokamaks from Faraday rotation measurements.}, keywords = {tomography } }