@article{Sawamoto2006, title = {New neurons follow the flow of cerebrospinal fluid in the adult brain.}, author = {Kazunobu Sawamoto and Hynek Wichterle and Oscar Gonzalez-Perez and Jeremy A Cholfin and Masayuki Yamada and Nathalie Spassky and Noel S Murcia and Jose Manuel Garcia-Verdugo and Oscar Marin and John L R Rubenstein and Marc Tessier-Lavigne and Hideyuki Okano and Arturo Alvarez-Buylla}, journal = {Science}, month = {Feb}, number = {5761}, pages = {629--632}, url = {http://dx.doi.org/10.1126/science.1119133}, volume = {311}, year = {2006}, biburl = {http://www.bibsonomy.org/bibtex/2bb9d18e5f35ea597a95471d5b9105402/leinweber}, abstract = {In the adult brain, neuroblasts born in the subventricular zone migrate from the walls of the lateral ventricles to the olfactory bulb. How do these cells orient over such a long distance and through complex territories? Here we show that neuroblast migration parallels cerebrospinal fluid (CSF) flow. Beating of ependymal cilia is required for normal CSF flow, concentration gradient formation of CSF guidance molecules, and directional migration of neuroblasts. Results suggest that polarized epithelial cells contribute important vectorial information for guidance of young, migrating neurons.}, doi = {10.1126/science.1119133}, owner = {leinweber}, file = {sawamoto2006_New Neurons Follow the Flow of Cerebrospinal Fluid in the Adult Brain.pdf:sawamoto2006_New Neurons Follow the Flow of Cerebrospinal Fluid in the Adult Brain.pdf:PDF}, pii = {1119133}, pmid = {16410488}, timestamp = {2006.03.23}, keywords = {system:unfiled } }