@article{fuchs_proteome_2007, title = {Proteome analysis suggests that mitochondrial dysfunction in stressed endothelial cells is reversed by a soy extract and isolated isoflavones}, author = {Dagmar Fuchs and Barbara Dirscherl and Joyce H Schroot and Hannelore Daniel and Uwe Wenzel}, journal = {Journal of proteome research}, pages = {2132-42}, volume = {6}, year = {2007}, biburl = {http://www.bibsonomy.org/bibtex/2eecdfce895746a0e03e751a0d961a54d/molnutrition}, abstract = {Apoptosis is a driving force in atherosclerosis development. A soy extract or a combination of the soy isoflavones genistein and daidzein inhibited apoptosis induced by oxidized LDL in endothelial cells. Proteome analysis revealed that the LDL-induced alterations of numerous proteins were reversed by the extract and the genistein/daidzein mixture but only three protein entities, all functionally linked to mitochondrial dysfunction, were regulated in common by both treatments.}, issn = {15353893}, keywords = {Apoptosis Endothelial_Cells Endothelium Genistein Humans IFZ Isoflavones LDL Lipoproteins Mass Matrix-Assisted_Laser_Desorption-Ionization Mitochondria Oxidation-Reduction Plant_Extracts Proteome Soybeans Spectrometry Vascular } }