@article{Rehman.2006, abstract = {The Notch signaling pathway is conserved in vertebrates and invertebrates and is involved in many developmental processes. Notch receptors and ligands are expressed on the cell surface enabling interactions between adjacent cells upon receptor-ligand binding. Notch signaling molecules have an important well-documented role in vascular development, differentiation, proliferation, apoptosis and tumorigenesis. Recently, several groups have identified the importance of Notch signaling in tumor angiogenesis. Notch activity increases specifically in tumor endothelium and in various tumors types and, in some studies, Notch signaling suppresses angiogenic processes. Because the Notch signaling pathway can mediate communication between various cell types in the tumor microenvironment, interactions between tumor cells and endothelial cells might promote angiogenesis, therefore targeting the Notch pathway might provide a novel strategy for anti-angiogenic therapies. Here, we discuss recent insigh}, added-at = {2010-02-05T11:28:39.000+0100}, author = {Rehman, A. O. and Wang, C. Y.}, biburl = {http://www.bibsonomy.org/bibtex/267ae74502331a25b179814c5fd6bc59c/kanefendt}, interhash = {ae984c5d245a44b75895bf3a5d0c1c73}, intrahash = {67ae74502331a25b179814c5fd6bc59c}, journal = {Trends Cell Biol.}, keywords = {& Agents Angiogenesis Animals Binding Biological Blood Carcinogens Cells Endothelial Genes Humans Inducing Inhibitors Laboratories Ligands Models Neoplasms Neovascularization Notch Pathologic Receptors Signal Suppressor Transduction Tumor Vessels blood cells development growth metabolism physiology supply therapy}, number = 6, pages = {293-300}, timestamp = {2010-02-05T11:28:39.000+0100}, title = {Notch signaling in the regulation of tumor angiogenesis}, url = {PM:16697642}, volume = 16, year = 2006 } @article{Saharinen.2004, added-at = {2010-02-05T11:28:39.000+0100}, author = {Saharinen, P. and Tammela, T. and Karkkainen, M. J. and Alitalo, K.}, biburl = {http://www.bibsonomy.org/bibtex/2ec83166e1508a44964475223927b4d07/kanefendt}, interhash = {27a893f0f8ab17a22b0f3c39f49614c8}, intrahash = {ec83166e1508a44964475223927b4d07}, journal = {Trends Immunol.}, keywords = {Animals C Cells D Endothelial Factor Growth Homeodomain Humans Inflammation Laboratories Lymphangiogenesis Lymphatic Lymphedema Metastasis Neoplasm Proteins Receptor-3 Receptors Research Suppressor Tumor Vascular Vessels embryology metabolism physiology physiopathology protein}, number = 7, pages = {387-395}, timestamp = {2010-02-05T11:28:39.000+0100}, title = {Lymphatic vasculature: development, molecular regulation and role in tumor metastasis and inflammation}, url = {PM:15207507}, volume = 25, year = 2004 } @article{Oliver.2002, added-at = {2010-02-05T11:28:39.000+0100}, author = {Oliver, G. and Detmar, M.}, biburl = {http://www.bibsonomy.org/bibtex/2725b6001d704922f3a99f2b711324a29/kanefendt}, interhash = {fa47e29a89e5c3276b700424e7996383}, intrahash = {725b6001d704922f3a99f2b711324a29}, journal = {Genes Dev.}, keywords = {Animals Biological Cytoplasm Diseases Factors Fluorescence Homeodomain Humans Lymphatic Mice Microscopy Models Proteins Research Suppressor System Time Tumor diagnosis embryology genetics metabolism physiology protein}, number = 7, pages = {773-783}, timestamp = {2010-02-05T11:28:39.000+0100}, title = {The rediscovery of the lymphatic system: old and new insights into the development and biological function of the lymphatic vasculature}, url = {PM:11937485}, volume = 16, year = 2002 }