Article,

Hydrangenone, a New Isoprenoid with an Unprecedented Skeleton from Salvia hydrangea

, , , , , , , and .
ORGANIC LETTERS, 14 (1): 166-169 (January 2012)
DOI: {10.1021/ol202953b}

Abstract

Hydrangenone, a new heptacyclic isoprenoid with a 6/7/6/5/5 membered carbon ring skeleton, was Isolated from the aerial parts of Salvia hydrangea. The structure was established by extensive NMR spectroscopic methods. The relative and absolute configuration of 1 was assigned by NOESY and X-ray crystallographic analysis and by comparison of experimental and calculated electronic circular dichroism (ECD) spectra. Compound 1 showed in vitro antiplasmodial activity, with an IC50 value of 1.4 mu M against P. falciparum. A plausible biosynthetic pathway of 1 was also proposed.

Tags

Users

  • @hkhavasi

Comments and Reviews