%0 Journal Article %1 Rodriguez-Segade1989 %A Rodriguez-Segade, S. %A de la Pe?a, C. A. %A Tutor, J. C. %A Paz, J. M. %A Fernandez, M. P. %A Rozas, I. %A R?o, R. Del %D 1989 %J Clin Chim Acta %K Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Carnitine; Cerebral Palsy; Drug Therapy, Combination; Female; Humans; Male; Middle Phenobarbital; Phenytoin; Seizures; Valproic Acid %N 2 %P 175--181 %T Carnitine deficiency associated with anticonvulsant therapy. %V 181 %X Valproic acid therapy is known to be associated with carnitine deficiency in adult as well as young epileptic patients. In a study of the possible existence of such side-effects with other anticonvulsants, 76.5\% of adult patients treated with valproate were deficient in serum free carnitine, with acylcarnitine levels significantly higher than in controls (p less than 0.01), while the carnitine deficiency rate in a group of patients treated with anticonvulsants other than valproate was 21.5\%. Since in clinical practice only about one fifth of patients are treated with valproate, this means that about 15\% of epileptics are carnitine deficient because of valproate treatment and 17\% because of other anticonvulsants. The mechanisms and clinical and biological consequences of the carnitine deficiency associated with antiepileptic drugs other than valproate are not known.

@article{Rodriguez-Segade1989, abstract = {Valproic acid therapy is known to be associated with carnitine deficiency in adult as well as young epileptic patients. In a study of the possible existence of such side-effects with other anticonvulsants, 76.5\% of adult patients treated with valproate were deficient in serum free carnitine, with acylcarnitine levels significantly higher than in controls (p less than 0.01), while the carnitine deficiency rate in a group of patients treated with anticonvulsants other than valproate was 21.5\%. Since in clinical practice only about one fifth of patients are treated with valproate, this means that about 15\% of epileptics are carnitine deficient because of valproate treatment and 17\% because of other anticonvulsants. The mechanisms and clinical and biological consequences of the carnitine deficiency associated with antiepileptic drugs other than valproate are not known.}, added-at = {2014-07-19T21:08:58.000+0200}, author = {Rodriguez-Segade, S. and de la Pe?a, C. A. and Tutor, J. C. and Paz, J. M. and Fernandez, M. P. and Rozas, I. and R?o, R. Del}, biburl = {https://www.bibsonomy.org/bibtex/22b2d458c1d4c25ac0d815b348c783ea6/ar0berts}, groups = {public}, interhash = {0ca4c43268a0936d5e4d56325303f3d9}, intrahash = {2b2d458c1d4c25ac0d815b348c783ea6}, journal = {Clin Chim Acta}, keywords = {Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Carnitine; Cerebral Palsy; Drug Therapy, Combination; Female; Humans; Male; Middle Phenobarbital; Phenytoin; Seizures; Valproic Acid}, month = May, number = 2, pages = {175--181}, pii = {0009-8981(89)90185-X}, pmid = {2500272}, timestamp = {2014-07-19T21:08:58.000+0200}, title = {Carnitine deficiency associated with anticonvulsant therapy.}, username = {ar0berts}, volume = 181, year = 1989 }