%0 Journal Article %1 parrish2016endogenized %A Parrish, Nicholas F. %A Tomonaga, Keizo %D 2016 %J Current Opinion in Microbiology %K development retroviruses review selfish_elements %P 176--183 %R 10.1016/j.mib.2016.03.002 %T Endogenized viral sequences in mammals %U https://doi.org/10.1016%2Fj.mib.2016.03.002 %V 31 %X Reverse-transcribed RNA molecules compose a significant portion of the human genome. Many of these RNA molecules were retrovirus genomes either infecting germline cells or having done so in a previous generation but retaining transcriptional activity. This mechanism itself accounts for a quarter of the genomic sequence information of mammals for which there is data. We understand relatively little about the causes and consequences of retroviral endogenization. This review highlights functions ascribed to sequences of viral origin endogenized into mammalian genomes and suggests some of the most pressing questions raised by these observations.

@article{parrish2016endogenized, abstract = {Reverse-transcribed RNA molecules compose a significant portion of the human genome. Many of these RNA molecules were retrovirus genomes either infecting germline cells or having done so in a previous generation but retaining transcriptional activity. This mechanism itself accounts for a quarter of the genomic sequence information of mammals for which there is data. We understand relatively little about the causes and consequences of retroviral endogenization. This review highlights functions ascribed to sequences of viral origin endogenized into mammalian genomes and suggests some of the most pressing questions raised by these observations.}, added-at = {2017-07-25T17:57:53.000+0200}, author = {Parrish, Nicholas F. and Tomonaga, Keizo}, biburl = {https://www.bibsonomy.org/bibtex/225600eef762ab12f35fbf0937c4d1cc4/peter.ralph}, doi = {10.1016/j.mib.2016.03.002}, interhash = {111b9eca685135e562d9d2f4b6f633ad}, intrahash = {25600eef762ab12f35fbf0937c4d1cc4}, journal = {Current Opinion in Microbiology}, keywords = {development retroviruses review selfish_elements}, month = jun, pages = {176--183}, timestamp = {2017-07-25T17:57:53.000+0200}, title = {Endogenized viral sequences in mammals}, url = {https://doi.org/10.1016%2Fj.mib.2016.03.002}, volume = 31, year = 2016 }