%0 Journal Article %1 Tsirlis.2008 %A Tsirlis, T. D. %A Papastratis, G. %A Masselou, K. %A Tsigris, C. %A Papachristodoulou, A. %A Kostakis, A. %A Nikiteas, N. I. %D 2008 %J World J.Gastroenterol. %K Biological C Chain Colorectal D Endothelial Esophageal Factor Gastrointestinal Growth Human Humans Immunohistochemistry Inflammation Ligands Lymphangiogenesis Lymphatic Markers Metastasis Neoplasm Neoplasms Polymerase Predictive Prognosis Reaction Receptor-3 Staging Stomach System Tests Tumor Value Vascular Vessels blood metabolism mortality of pathology physiopathology surgery %N 17 %P 2691-2701 %T Circulating lymphangiogenic growth factors in gastrointestinal solid tumors, could they be of any clinical significance? %U PM:18461654 %V 14 %X Metastasis is the principal cause of cancer mortality, with the lymphatic system being the first route of tumor dissemination. The glycoproteins VEGF-C and VEGF-D are members of the vascular endothelial growth factor (VEGF) family, whose role has been recently recognized as lymphatic system regulators during embryogenesis and in pathological processes such as inflammation, lymphatic system disorders and malignant tumor metastasis. They are ligands for the VEGFR-3 receptor on the membrane of the lymphatic endothelial cell, resulting in dilatation of existing lymphatic vessels as well as in vegetation of new ones (lymphangiogenesis). Their determination is feasible in the circulating blood by immunoabsorption and in the tissue specimen by immunohistochemistry and reverse transcription polymerase chain reaction (RT-PCR). Experimental and clinicopathological studies have linked the VEGF-C, VEGF-D/VEGFR3 axis to lymphatic spread as well as to the clinical outcome in several human solid tumo

@article{Tsirlis.2008, abstract = {Metastasis is the principal cause of cancer mortality, with the lymphatic system being the first route of tumor dissemination. The glycoproteins VEGF-C and VEGF-D are members of the vascular endothelial growth factor (VEGF) family, whose role has been recently recognized as lymphatic system regulators during embryogenesis and in pathological processes such as inflammation, lymphatic system disorders and malignant tumor metastasis. They are ligands for the VEGFR-3 receptor on the membrane of the lymphatic endothelial cell, resulting in dilatation of existing lymphatic vessels as well as in vegetation of new ones (lymphangiogenesis). Their determination is feasible in the circulating blood by immunoabsorption and in the tissue specimen by immunohistochemistry and reverse transcription polymerase chain reaction (RT-PCR). Experimental and clinicopathological studies have linked the VEGF-C, VEGF-D/VEGFR3 axis to lymphatic spread as well as to the clinical outcome in several human solid tumo}, added-at = {2010-02-05T11:28:39.000+0100}, author = {Tsirlis, T. D. and Papastratis, G. and Masselou, K. and Tsigris, C. and Papachristodoulou, A. and Kostakis, A. and Nikiteas, N. I.}, biburl = {https://www.bibsonomy.org/bibtex/241678b8d9524b672b49f2f13e1816a8b/kanefendt}, interhash = {2032494e106095441990a9f3e417803e}, intrahash = {41678b8d9524b672b49f2f13e1816a8b}, journal = {World J.Gastroenterol.}, keywords = {Biological C Chain Colorectal D Endothelial Esophageal Factor Gastrointestinal Growth Human Humans Immunohistochemistry Inflammation Ligands Lymphangiogenesis Lymphatic Markers Metastasis Neoplasm Neoplasms Polymerase Predictive Prognosis Reaction Receptor-3 Staging Stomach System Tests Tumor Value Vascular Vessels blood metabolism mortality of pathology physiopathology surgery}, number = 17, pages = {2691-2701}, timestamp = {2010-02-05T11:28:50.000+0100}, title = {Circulating lymphangiogenic growth factors in gastrointestinal solid tumors, could they be of any clinical significance?}, url = {PM:18461654}, volume = 14, year = 2008 }