Abstract
The Ensembl (http://www.ensembl.org/) database project provides a
bioinformatics framework to organise biology around the sequences
of large genomes. It is a comprehensive source of stable automatic
annotation of the human genome sequence, with confirmed gene predictions
that have been integrated with external data sources, and is available
as either an interactive web site or as flat files. It is also an
open source software engineering project to develop a portable system
able to handle very large genomes and associated requirements from
sequence analysis to data storage and visualisation. The Ensembl
site is one of the leading sources of human genome sequence annotation
and provided much of the analysis for publication by the international
human genome project of the draft genome. The Ensembl system is being
installed around the world in both companies and academic sites on
machines ranging from supercomputers to laptops.
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