Article,

Hepoxilin A3 (HXA3) synthase deficiency is causative of a novel ichthyosis form

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FEBS Lett, 582 (2): 279-85 (January 2008)Nigam, Santosh Zafiriou, Maria-Patapia Deva, Rupal Kerstin, Nadja Geilen, Christoph Ciccoli, Roberto Sczepanski, Marco Lohse, Maren Research Support, Non-U.S. Gov't Netherlands FEBS letters FEBS Lett. 2008 Jan 23;582(2):279-85. Epub 2007 Dec 18..

Abstract

Non-bullous congenital ichthyosis erythroderma (NCIE) and lamellar ichthyosis (LI) are characterized by mutations in 12R-lipoxygenase (12R-LOX) and/or epidermal lipoxygenase 3 (eLOX3) enzymes. The eLOX3 lacks oxygenase activity, but is capable of forming hepoxilin-type products from arachidonic acid-derived hydroperoxide from 12R-LOX, termed 12R-hydroperoxyeicosa-5,8,10,14-tetraenoic acid (12R-HpETE). Mutations in either of two enzymes lead to NCIE or LI. Moreover, 12R-LOX-deficient mice exhibit severe phenotypic water barrier dysfunctions. Here, we demonstrate that 12R-HpETE can also be transformed to 8R-HXA(3) by hepoxilin A(3) (HXA(3)) synthase (12-lipoxygenase), which exhibits oxygenase activity. We also presented a novel form of ichthyosis in a patient, termed hepoxilin A(3) synthase-linked ichthyosis (HXALI), whose scales expressed high levels of 12R-LOX, but were deficient of HXA(3) synthase.

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