%0 Journal Article %1 Wang2007a %A Wang, Gang G. %A Allis, C. David %A Chi, Ping %D 2007 %J Trends Mol Med %K Adenosine_Triphosphate,_metabolism/physiology Animals Chromatin,_metabolism/physiology Histones,_chemistry/metabolism Humans Models,_Biological Neoplasms,_metabolism/physiopathology Protein_Processing,_Post-Translational %N 9 %P 373-380 %R 10.1016/j.molmed.2007.07.004 %T Chromatin remodeling and cancer, Part II: ATP-dependent chromatin remodeling. %U http://dx.doi.org/10.1016/j.molmed.2007.07.004 %V 13 %X Connections between perturbations that lie outside of our genome, that is, epigenetic alternations, and tumorigenesis have become increasingly apparent. Dynamic chromatin remodeling of the fundamental nucleosomal structure (covered in this review) or the covalent marks residing in the histone proteins that make up this structure (covered previously in part I) underlie many fundamental cellular processes, including transcriptional regulation and DNA-damage repair. Dysregulation of these processes has been linked to cancer development. Mechanisms of chromatin remodeling include dynamic interplay between ATP-dependent complexes, covalent histone modifications, utilization of histone variants and DNA methylation. In part II of this series, we focus on connections between ATP-dependent chromatin-remodeling complexes and oncogenesis and discuss the potential clinical implications of chromatin remodeling and cancer.

@article{Wang2007a, abstract = {Connections between perturbations that lie outside of our genome, that is, epigenetic alternations, and tumorigenesis have become increasingly apparent. Dynamic chromatin remodeling of the fundamental nucleosomal structure (covered in this review) or the covalent marks residing in the histone proteins that make up this structure (covered previously in part I) underlie many fundamental cellular processes, including transcriptional regulation and DNA-damage repair. Dysregulation of these processes has been linked to cancer development. Mechanisms of chromatin remodeling include dynamic interplay between ATP-dependent complexes, covalent histone modifications, utilization of histone variants and DNA methylation. In part II of this series, we focus on connections between ATP-dependent chromatin-remodeling complexes and oncogenesis and discuss the potential clinical implications of chromatin remodeling and cancer.}, added-at = {2010-01-26T20:35:53.000+0100}, author = {Wang, Gang G. and Allis, C. David and Chi, Ping}, biburl = {https://www.bibsonomy.org/bibtex/2a95940a5d20f03c9049fab88982730ed/denilw}, doi = {10.1016/j.molmed.2007.07.004}, file = {article:../Chromatin/Chromatin remodeling and cancer%2C Part I%3A Covalent histone modfications.pdf:pdf}, institution = {Laboratory of Chromatin Biology, The Rockefeller University, and Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.}, interhash = {4d93a6a9c4645061267bfba2e39eef4b}, intrahash = {a95940a5d20f03c9049fab88982730ed}, journal = {Trends Mol Med}, keywords = {Adenosine_Triphosphate,_metabolism/physiology Animals Chromatin,_metabolism/physiology Histones,_chemistry/metabolism Humans Models,_Biological Neoplasms,_metabolism/physiopathology Protein_Processing,_Post-Translational}, month = Sep, number = 9, owner = {denilw}, pages = {373-380}, pii = {S1471-4914(07)00147-5}, pmid = {17822959}, timestamp = {2010-01-26T20:36:04.000+0100}, title = {Chromatin remodeling and cancer, Part II: ATP-dependent chromatin remodeling.}, url = {http://dx.doi.org/10.1016/j.molmed.2007.07.004}, volume = 13, year = 2007 }