%0 Journal Article %1 corbettdetig2012population %A Corbett-Detig, Russell B. %A Hartl, Daniel L. %D 2012 %I Public Library of Science %J PLoS Genet %K Drosophila inversions population_genomics %N 12 %P e1003056 %R 10.1371/journal.pgen.1003056 %T Population Genomics of Inversion Polymorphisms in Drosophila melanogaster %U http://dx.doi.org/10.1371%2Fjournal.pgen.1003056 %V 8 %X Chromosomal inversions are known to respond to powerful natural selection in many species. Despite this evidence, little progress has been made towards understanding the nature of selection that affects inversions. Here, we utilize two recently released population-resequencing projects from <italic>D. melanogaster</italic> to address many of the unknown features of polymorphic inversions. We find evidence that inversions in this species are generally very young, with ages on the order of hundreds to tens of thousands of years, and that the majority of inversions originated in ancestral African populations. Inversions are also the source of the majority of genetic structure within populations and affect polymorphism chromosome-wide. We are able to confirm experimentally that one X-chromosome inversion achieves an advantage by selfishly increasing its transmission through males. Future work will build on our basic inferences to identify potential selective mechanisms and candidate genes in the other inversions studied.

@article{corbettdetig2012population, abstract = {Chromosomal inversions are known to respond to powerful natural selection in many species. Despite this evidence, little progress has been made towards understanding the nature of selection that affects inversions. Here, we utilize two recently released population-resequencing projects from <italic>D. melanogaster</italic> to address many of the unknown features of polymorphic inversions. We find evidence that inversions in this species are generally very young, with ages on the order of hundreds to tens of thousands of years, and that the majority of inversions originated in ancestral African populations. Inversions are also the source of the majority of genetic structure within populations and affect polymorphism chromosome-wide. We are able to confirm experimentally that one X-chromosome inversion achieves an advantage by selfishly increasing its transmission through males. Future work will build on our basic inferences to identify potential selective mechanisms and candidate genes in the other inversions studied. }, added-at = {2015-04-08T22:16:35.000+0200}, author = {Corbett-Detig, Russell B. and Hartl, Daniel L.}, biburl = {https://www.bibsonomy.org/bibtex/2994dd7dc827c1b4303457c6491efa4a2/peter.ralph}, doi = {10.1371/journal.pgen.1003056}, interhash = {6db5be865dfc0992c7141f8bed676698}, intrahash = {994dd7dc827c1b4303457c6491efa4a2}, journal = {PLoS Genet}, keywords = {Drosophila inversions population_genomics}, month = {12}, number = 12, pages = {e1003056}, publisher = {Public Library of Science}, timestamp = {2015-04-08T22:16:35.000+0200}, title = {Population Genomics of Inversion Polymorphisms in \textit{{Drosophila} melanogaster} }, url = {http://dx.doi.org/10.1371%2Fjournal.pgen.1003056}, volume = 8, year = 2012 }