%0 Journal Article %1 Schwab2004 %A Schwab, K. O. %A Menche, U. %A Schmeisl, G. %A Lohse, M. J. %D 2004 %J Horm Res %K 1/*metabolism/psychology Adolescent Adult Aged Awareness/*physiology Diabetes Down-Regulation Female Humans Hypoglycemia/*metabolism/psychology Male Mellitus, Middle Nervous Signal Sympathetic System/physiology Transduction Type beta-2/*metabolism Receptor Adrenergic %N 3 %P 137-41 %T Hypoglycemia-dependent beta2-adrenoceptor downregulation: a contributing factor to hypoglycemia unawareness in patients with Type-1 diabetes? %U http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15297801 %V 62 %X To evaluate the influence of the incidence and unawareness of hypoglycemia on lymphocyte beta2-adrenoceptor densities, we measured beta2-adrenoceptor density using 125I-iodocyanopindolol and CGP 12177 before and after 1 week of treatment optimization in 33 adults with type-1 diabetes mellitus. Diabetes treatment of all patients was modified to improve their glycemic control. During this week, all patients had to complete a protocol with 7 daily glucose measurements, one of which was at night. The subjective symptoms were evaluated in case of hypoglycemia. A significant correlation between a hypoglycemia incidence below (but not above) the threshold of 2.75 mmol/l (50 mg/dl) and beta2-adrenoceptor densities on lymphocytes was found after the study week (r = -0.72, p < 0.00001). Nine patients suffering from hypoglycemia unawareness had a significantly higher incidence of hypoglycemia (p < 0.002) and lower beta2-adrenoceptor densities on lymphocytes compared to 24 patients who recognized all of their hypoglycemic episodes (p < 0.004). We conclude that downregulation of beta2-adrenoceptor densities on lymphocytes occurs as a result of recurrent hypoglycemia defined as glucose levels of < 2.75 mmol/l. Beta2-adrenoceptor densities are decreased in patients with subjective hypoglycemia unawareness and might contribute to the reduced beta-adrenergic sensitivity in this subgroup of patients.

@article{Schwab2004, abstract = {To evaluate the influence of the incidence and unawareness of hypoglycemia on lymphocyte beta2-adrenoceptor densities, we measured beta2-adrenoceptor density using [125I]-iodocyanopindolol and CGP 12177 before and after 1 week of treatment optimization in 33 adults with type-1 diabetes mellitus. Diabetes treatment of all patients was modified to improve their glycemic control. During this week, all patients had to complete a protocol with 7 daily glucose measurements, one of which was at night. The subjective symptoms were evaluated in case of hypoglycemia. A significant correlation between a hypoglycemia incidence below (but not above) the threshold of 2.75 mmol/l (50 mg/dl) and beta2-adrenoceptor densities on lymphocytes was found after the study week (r = -0.72, p < 0.00001). Nine patients suffering from hypoglycemia unawareness had a significantly higher incidence of hypoglycemia (p < 0.002) and lower beta2-adrenoceptor densities on lymphocytes compared to 24 patients who recognized all of their hypoglycemic episodes (p < 0.004). We conclude that downregulation of beta2-adrenoceptor densities on lymphocytes occurs as a result of recurrent hypoglycemia defined as glucose levels of < 2.75 mmol/l. Beta2-adrenoceptor densities are decreased in patients with subjective hypoglycemia unawareness and might contribute to the reduced beta-adrenergic sensitivity in this subgroup of patients.}, added-at = {2010-12-14T18:12:02.000+0100}, author = {Schwab, K. O. and Menche, U. and Schmeisl, G. and Lohse, M. J.}, biburl = {https://www.bibsonomy.org/bibtex/2af72ea756310831e71015dada356bc7c/pharmawuerz}, endnotereftype = {Journal Article}, interhash = {cea10bdbdafb2a29973b8fab0eadb9df}, intrahash = {af72ea756310831e71015dada356bc7c}, issn = {0301-0163 (Print) 0301-0163 (Linking)}, journal = {Horm Res}, keywords = {1/*metabolism/psychology Adolescent Adult Aged Awareness/*physiology Diabetes Down-Regulation Female Humans Hypoglycemia/*metabolism/psychology Male Mellitus, Middle Nervous Signal Sympathetic System/physiology Transduction Type beta-2/*metabolism Receptor Adrenergic}, note = {Schwab, K O Menche, U Schmeisl, G Lohse, M J Research Support, Non-U.S. Gov't Switzerland Hormone research Horm Res. 2004;62(3):137-41. Epub 2004 Aug 3.}, number = 3, pages = {137-41}, shorttitle = {Hypoglycemia-dependent beta2-adrenoceptor downregulation: a contributing factor to hypoglycemia unawareness in patients with Type-1 diabetes?}, timestamp = {2010-12-14T18:22:42.000+0100}, title = {Hypoglycemia-dependent beta2-adrenoceptor downregulation: a contributing factor to hypoglycemia unawareness in patients with Type-1 diabetes?}, url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15297801}, volume = 62, year = 2004 }