Article,
Network biology: understanding the cell's functional organization
Nat Rev Genet, 5 (2): 101--113 (Feb 1, 2004)
DOI: 10.1038/nrg1272
Abstract
A key aim of postgenomic biomedical research is to systematically catalogue all molecules and their interactions within a living cell. There is a clear need to understand how these molecules and the interactions between them determine the function of this enormously complex machinery, both in isolation and when surrounded by other cells. Rapid advances in network biology indicate that cellular networks are governed by universal laws and offer a new conceptual framework that could potentially revolutionize our view of biology and disease pathologies in the twenty-first century.
