%0 Journal Article %1 Valkama2001 %A Valkama, A. M. %A Tolonen, E. U. %A Kerttul, L. I. %A P??kk?, E. L. %A Vainionp??, L. K. %A Koivist, M. E. %D 2001 %J Acta Paediatr %K Brain Stem; Cerebral Palsy; Cohort Studies; Deafness; Evoked Potentials, Auditory, Female; Follow-Up Humans; Infant, Newborn; Premature; Magnetic Resonance Imaging; Male; Sensitivity and Specificity %N 8 %P 909--915 %T Brainstem size and function at term age in relation to later neurosensory disability in high-risk, preterm infants. %V 90 %X The aim of this study was to measure brainstem size on magnetic resonance imaging (MRI) scans of high-risk. preterm infants, to assess brainstem function by brainstem auditory-evoked potentials (BAEP) and to determine the predictive value of these measures for the neurosensory outcome. A total of 51 preterm infants (gestational age <34 wk, birthweight <1,500 g) underwent examinations at term age; neuromotor outcome and hearing were followed up until a corrected age of 18 mo. Fourteen (27\%) infants had neurosensory disability. Those with a later neurosensory disability had a significantly smaller brain stem than those with a normal outcome. The preterm infants had significantly longer peak latency (L) V and interpeak latency (IPL) III-V than the full-term control infants. Most of the preterm infants with severe cerebral palsy or hearing loss had abnormal BAEP. Sensitivity of morphometric dimensions for predicting neurosensory disability was only 20-31\%, but specificity was 97-100\%. Abnormal L I and IPL III-V in BAEP predicted disability with a sensitivity of 93\% and a specificity of 57-59\%. CONCLUSION: We conclude that adverse events during the perinatal period may lead to morphofunctional changes in the brain stem in high-risk, preterm infants, and it seems that functional changes are accurate in predicting neurosensory disability in such patients.

@article{Valkama2001, abstract = {The aim of this study was to measure brainstem size on magnetic resonance imaging (MRI) scans of high-risk. preterm infants, to assess brainstem function by brainstem auditory-evoked potentials (BAEP) and to determine the predictive value of these measures for the neurosensory outcome. A total of 51 preterm infants (gestational age <34 wk, birthweight <1,500 g) underwent examinations at term age; neuromotor outcome and hearing were followed up until a corrected age of 18 mo. Fourteen (27\%) infants had neurosensory disability. Those with a later neurosensory disability had a significantly smaller brain stem than those with a normal outcome. The preterm infants had significantly longer peak latency (L) V and interpeak latency (IPL) III-V than the full-term control infants. Most of the preterm infants with severe cerebral palsy or hearing loss had abnormal BAEP. Sensitivity of morphometric dimensions for predicting neurosensory disability was only 20-31\%, but specificity was 97-100\%. Abnormal L I and IPL III-V in BAEP predicted disability with a sensitivity of 93\% and a specificity of 57-59\%. CONCLUSION: We conclude that adverse events during the perinatal period may lead to morphofunctional changes in the brain stem in high-risk, preterm infants, and it seems that functional changes are accurate in predicting neurosensory disability in such patients.}, added-at = {2014-07-19T21:50:40.000+0200}, author = {Valkama, A. M. and Tolonen, E. U. and Kerttul, L. I. and P??kk?, E. L. and Vainionp??, L. K. and Koivist, M. E.}, biburl = {https://www.bibsonomy.org/bibtex/2edb7ef34ae6bc9889ba6854b88a4b0da/ar0berts}, groups = {public}, interhash = {dd0a5a06245ae792c96b3ee3b3af53ca}, intrahash = {edb7ef34ae6bc9889ba6854b88a4b0da}, journal = {Acta Paediatr}, keywords = {Brain Stem; Cerebral Palsy; Cohort Studies; Deafness; Evoked Potentials, Auditory, Female; Follow-Up Humans; Infant, Newborn; Premature; Magnetic Resonance Imaging; Male; Sensitivity and Specificity}, month = Aug, number = 8, pages = {909--915}, pmid = {11529541}, timestamp = {2014-07-19T21:50:40.000+0200}, title = {Brainstem size and function at term age in relation to later neurosensory disability in high-risk, preterm infants.}, username = {ar0berts}, volume = 90, year = 2001 }