%0 Journal Article %1 Carman:2006:Trends-Biochem-Sci:17079146 %A Carman, G M %A Han, G S %D 2006 %J Trends Biochem Sci %K ARTICULOS FOSFATASA %N 12 %P 694-699 %R 10.1016/j.tibs.2006.10.003 %T Roles of phosphatidate phosphatase enzymes in lipid metabolism %U http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1769311/ %V 31 %X Phosphatidate phosphatase (PAP) enzymes catalyze the dephosphorylation of phosphatidate, yielding diacylglycerol and inorganic phosphate. In eukaryotic cells, PAP activity has a central role in the synthesis of phospholipids and triacylglycerol through its product diacylglycerol, and it also generates and/or degrades lipid-signaling molecules that are related to phosphatidate. There are two types of PAP enzyme, Mg(2+) dependent (PAP1) and Mg(2+) independent (PAP2), but only genes encoding PAP2 enzymes had been identified until recently, when a gene (PAH1) encoding a PAP1 enzyme was found in Saccharomyces cerevisiae. This discovery has revealed a molecular function of the mammalian protein lipin, a deficiency of which causes lipodystrophy in mice. With molecular information now available for both types of PAP, the specific roles of these enzymes in lipid metabolism are being clarified.

@article{Carman:2006:Trends-Biochem-Sci:17079146, abstract = {Phosphatidate phosphatase (PAP) enzymes catalyze the dephosphorylation of phosphatidate, yielding diacylglycerol and inorganic phosphate. In eukaryotic cells, PAP activity has a central role in the synthesis of phospholipids and triacylglycerol through its product diacylglycerol, and it also generates and/or degrades lipid-signaling molecules that are related to phosphatidate. There are two types of PAP enzyme, Mg(2+) dependent (PAP1) and Mg(2+) independent (PAP2), but only genes encoding PAP2 enzymes had been identified until recently, when a gene (PAH1) encoding a PAP1 enzyme was found in Saccharomyces cerevisiae. This discovery has revealed a molecular function of the mammalian protein lipin, a deficiency of which causes lipodystrophy in mice. With molecular information now available for both types of PAP, the specific roles of these enzymes in lipid metabolism are being clarified.}, added-at = {2014-08-09T00:59:31.000+0200}, author = {Carman, G M and Han, G S}, biburl = {https://www.bibsonomy.org/bibtex/2b28d79c39019b966bb8504815200707d/elira}, description = {Roles of phosphatidate phosphatase enzymes in lipid metabolism}, doi = {10.1016/j.tibs.2006.10.003}, interhash = {e534afc7d85104808160736874c7f092}, intrahash = {b28d79c39019b966bb8504815200707d}, journal = {Trends Biochem Sci}, keywords = {ARTICULOS FOSFATASA}, month = dec, number = 12, pages = {694-699}, pmid = {17079146}, timestamp = {2014-08-09T01:02:40.000+0200}, title = {Roles of phosphatidate phosphatase enzymes in lipid metabolism}, url = {http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1769311/}, volume = 31, year = 2006 }