%0 Journal Article %1 Vohr1999 %A Vohr, B. %A Allan, W. C. %A Scott, D. T. %A Katz, K. H. %A Schneider, K. C. %A Makuch, R. W. %A Ment, L. R. %D 1999 %J Semin Perinatol %K Aging; Brain Diseases; Cerebral Hemorrhage; Palsy; Humans; Indomethacin; Infant, Newborn; Very Low Birth Weight; Intelligence Tests; Pros; pective Studies %N 3 %P 212--217 %T Early-onset intraventricular hemorrhage in preterm neonates: incidence of neurodevelopmental handicap. %V 23 %X The neurodevelopmental outcome of very low birth weight infants experiencing early-onset intraventricular hemorrhage (IVH) occurring within the first 6 postnatal hours was compared with that of their peers without early-onset IVH at 3 years corrected age. The 440 surviving preterm infants (birth weight 600 to 1,250 g) who had been enrolled in a multicenter, prospectively randomized, controlled trial evaluating the efficacy of postnatal indomethacin to prevent IVH were evaluated with the Stanford-Binet Intelligence Scale and neurological examinations at 3 years corrected age. All study infants had echoencephalography between 5 and 11 hours of life, and testing is reported for all children residing in English monolingual households at 3 years corrected age (i.e., from the obstetric due date). Fifty five of the 73 (75\%) infants with IVH within the first 5 to 11 hours survived to 3 years of age, compared with 385 of the 432 (89\%) children without early-onset hemorrhage who were alive at 3 years corrected age (P<.001). Eleven of the 29 (38\%) English monolingual children with early-onset IVH had Stanford-Binet intelligence quotient scores of less than 70, compared with 47 of the 249 (19\%) children without early IVH (P = .03). Similarly, 7 of 28 (25\%) early IVH children were found to have cerebral palsy, compared with 20 of 241 (8\%) children without early IVH (P = .01). These data suggest that infants who experience the early onset of IVH are at high risk for both cognitive and motor handicaps at 3 years corrected age.

@article{Vohr1999, abstract = {The neurodevelopmental outcome of very low birth weight infants experiencing early-onset intraventricular hemorrhage (IVH) occurring within the first 6 postnatal hours was compared with that of their peers without early-onset IVH at 3 years corrected age. The 440 surviving preterm infants (birth weight 600 to 1,250 g) who had been enrolled in a multicenter, prospectively randomized, controlled trial evaluating the efficacy of postnatal indomethacin to prevent IVH were evaluated with the Stanford-Binet Intelligence Scale and neurological examinations at 3 years corrected age. All study infants had echoencephalography between 5 and 11 hours of life, and testing is reported for all children residing in English monolingual households at 3 years corrected age (i.e., from the obstetric due date). Fifty five of the 73 (75\%) infants with IVH within the first 5 to 11 hours survived to 3 years of age, compared with 385 of the 432 (89\%) children without early-onset hemorrhage who were alive at 3 years corrected age (P<.001). Eleven of the 29 (38\%) English monolingual children with early-onset IVH had Stanford-Binet intelligence quotient scores of less than 70, compared with 47 of the 249 (19\%) children without early IVH (P = .03). Similarly, 7 of 28 (25\%) early IVH children were found to have cerebral palsy, compared with 20 of 241 (8\%) children without early IVH (P = .01). These data suggest that infants who experience the early onset of IVH are at high risk for both cognitive and motor handicaps at 3 years corrected age.}, added-at = {2014-07-19T21:53:34.000+0200}, author = {Vohr, B. and Allan, W. C. and Scott, D. T. and Katz, K. H. and Schneider, K. C. and Makuch, R. W. and Ment, L. R.}, biburl = {https://www.bibsonomy.org/bibtex/275dfe7d3b71ac3011ce52a5fa2b48197/ar0berts}, groups = {public}, interhash = {f5b6c4f2fba13dd39cd573a83adc1ed0}, intrahash = {75dfe7d3b71ac3011ce52a5fa2b48197}, journal = {Semin Perinatol}, keywords = {Aging; Brain Diseases; Cerebral Hemorrhage; Palsy; Humans; Indomethacin; Infant, Newborn; Very Low Birth Weight; Intelligence Tests; Pros; pective Studies}, month = Jun, number = 3, pages = {212--217}, pmid = {10405190}, timestamp = {2014-07-19T21:53:34.000+0200}, title = {Early-onset intraventricular hemorrhage in preterm neonates: incidence of neurodevelopmental handicap.}, username = {ar0berts}, volume = 23, year = 1999 }