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Vector seasonality, host infection dynamics and fitness of pathogens transmitted by the tick Ixodes scapularis.

by: N. H. Ogden, M. Bigras-Poulin, C. J. O'callaghan, I. K. Barker, K. Kurtenbach, L. R. Lindsay, and D. F. Charron

In: Parasitology, Vol. 134, Nr. Pt 2 (February 2007) , p. 209--227.

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URL:	http://dx.doi.org/10.1017/S0031182006001417
DOI:	10.1017/S0031182006001417

Fitness of tick-borne pathogens may be determined by the degree to which their infection dynamics in vertebrate hosts permits transmission cycles if infective and uninfected tick stages are active at different times of the year. To investigate this hypothesis we developed a simulation model that integrates the transmission pattern imposed by seasonally asynchronous nymphal and larval Ixodes scapularis ticks in northeastern North America, with a model of infection in white-footed mice Peromyscus leucopus reservoir hosts, using the bacteria Borrelia burgdorferi and Anaplasma phagocytophilum as examples. In simulations, survival of microparasites, their sensitivity to reduced rodent and tick abundance, and to 'dilution' by a reservoir-incompetent host depended on traits that allowed i highly efficient transmission from acutely-infected hosts, ii long-lived acute or 'carrier' host infections, and/or iii transmission amongst co-feeding ticks. Minimum values for transmission efficiency to ticks, and duration of host infectivity, necessary for microparasite persistence, were always higher when nymphal and larval ticks were seasonally asynchronous than when these instars were synchronous. Thus, traits influencing duration of host infectivity, transmission efficiency to ticks and co-feeding transmission are likely to be dominant determinants of fitness in I. scapularis-borne microparasites in northeastern North America due to abiotic forcings influencing I. scapularis seasonality.

BibTeX record

@article{Ogden2007,
  abstract = {Fitness of tick-borne pathogens may be determined by the degree to which their infection dynamics in vertebrate hosts permits transmission cycles if infective and uninfected tick stages are active at different times of the year. To investigate this hypothesis we developed a simulation model that integrates the transmission pattern imposed by seasonally asynchronous nymphal and larval Ixodes scapularis ticks in northeastern North America, with a model of infection in white-footed mice (Peromyscus leucopus) reservoir hosts, using the bacteria Borrelia burgdorferi and Anaplasma phagocytophilum as examples. In simulations, survival of microparasites, their sensitivity to reduced rodent and tick abundance, and to 'dilution' by a reservoir-incompetent host depended on traits that allowed (i) highly efficient transmission from acutely-infected hosts, (ii) long-lived acute or 'carrier' host infections, and/or (iii) transmission amongst co-feeding ticks. Minimum values for transmission efficiency to ticks, and duration of host infectivity, necessary for microparasite persistence, were always higher when nymphal and larval ticks were seasonally asynchronous than when these instars were synchronous. Thus, traits influencing duration of host infectivity, transmission efficiency to ticks and co-feeding transmission are likely to be dominant determinants of fitness in I. scapularis-borne microparasites in northeastern North America due to abiotic forcings influencing I. scapularis seasonality.},
  added-at = {2010-01-14T17:47:54.000+0100},
  author = {Ogden, N. H. and Bigras-Poulin, M. and O'callaghan, C. J. and Barker, I. K. and Kurtenbach, K. and Lindsay, L. R. and Charron, D. F.},
  biburl = {http://www.bibsonomy.org/bibtex/205c0790f0c0cf70f304ab34e21d7adc5/uvesco},
  doi = {10.1017/S0031182006001417},
  institution = {Faculté de médecine vétérinaire, Université de Montréal, C.P. 5000, Saint-Hyacinthe, QC, J2S 7C6, Canada. nicholas_ogden@phac-aspc.gc.ca},
  interhash = {5003e6ccf9cb915ad93621e477e9b011},
  intrahash = {05c0790f0c0cf70f304ab34e21d7adc5},
  journal = {Parasitology},
  keywords = {Ixodes ArachnidVectors DiseaseTransmission Animals model Anaplasmaphagocytophilum ComputerSimulation LymeDisease growth/&/development/pathogenicity transmission/veterinary Host-ParasiteInteractions Infectious Ehrlichiosis DiseaseReservoirs Borreliaburgdorferi Models veterinary Seasons Biological Peromyscus microbiology},
  language = {eng},
  medline-pst = {ppublish},
  month = Feb,
  note = {EFSA, abstract_only},
  number = {Pt 2},
  pages = {209--227},
  pii = {S0031182006001417},
  pmid = {17032476},
  timestamp = {2010-01-14T17:47:54.000+0100},
  title = {Vector seasonality, host infection dynamics and fitness of pathogens transmitted by the tick Ixodes scapularis.},
  url = {http://dx.doi.org/10.1017/S0031182006001417},
  volume = 134,
  year = 2007
}

Endnote record

%0 Journal Article
%1 Ogden2007
%A Ogden, N. H.
%A Bigras-Poulin, M.
%A O'callaghan, C. J.
%A Barker, I. K.
%A Kurtenbach, K.
%A Lindsay, L. R.
%A Charron, D. F.
%D 2007
%J Parasitology
%K 
%N Pt 2
%P 209--227
%T Vector seasonality, host infection dynamics and fitness of pathogens transmitted by the tick Ixodes scapularis.
%R 10.1017/S0031182006001417
%U http://dx.doi.org/10.1017/S0031182006001417
%V 134
%X Fitness of tick-borne pathogens may be determined by the degree to which their infection dynamics in vertebrate hosts permits transmission cycles if infective and uninfected tick stages are active at different times of the year. To investigate this hypothesis we developed a simulation model that integrates the transmission pattern imposed by seasonally asynchronous nymphal and larval Ixodes scapularis ticks in northeastern North America, with a model of infection in white-footed mice (Peromyscus leucopus) reservoir hosts, using the bacteria Borrelia burgdorferi and Anaplasma phagocytophilum as examples. In simulations, survival of microparasites, their sensitivity to reduced rodent and tick abundance, and to 'dilution' by a reservoir-incompetent host depended on traits that allowed (i) highly efficient transmission from acutely-infected hosts, (ii) long-lived acute or 'carrier' host infections, and/or (iii) transmission amongst co-feeding ticks. Minimum values for transmission efficiency to ticks, and duration of host infectivity, necessary for microparasite persistence, were always higher when nymphal and larval ticks were seasonally asynchronous than when these instars were synchronous. Thus, traits influencing duration of host infectivity, transmission efficiency to ticks and co-feeding transmission are likely to be dominant determinants of fitness in I. scapularis-borne microparasites in northeastern North America due to abiotic forcings influencing I. scapularis seasonality.

BibSonomy :: publication ::

Vector seasonality, host infection dynamics and fitness of pathogens transmitted by the tick Ixodes scapularis.

Resources (URL, PDF, PS...)

Abstract

BibTeX record

Endnote record