%0 Journal Article %1 Prinssen2004 %A Prinssen, M. %A Verhoeven, E. L. G. %A Buth, J. %A Cuypers, P. W. M. %A van Sambeek, M. R. H. M. %A Balm, R. %A Buskens, E. %A Grobbee, D. E. %A Blankensteijn, J. D. %A Pattynama, P. M. %A van Voorthuisen, A. E. %A Bak, A. A. A. %A Hunink, M. G. %A van Engelshoven, J. M. %A Jacobs, M. J. H. M. %A Mol, B. A. J. M. De %A van Bockel, J. H. %A Reekers, J. %A Tielbeek, X. %A Wisselink, W. %A Boekema, N. %A Sikking, I. %A Tielbeek, A. V. %A Reekers, J. A. %A Pattynama, P. %A Prins, T. %A van der Ham, A. C. %A van der Velden, J. J. I. M. %A van Sterkenburg, S. M. M. %A ten Haken, G. B. %A Bruijninckx, C. M. A. %A van Overhagen, H. %A Nolthenius, R. P. T. %A Hendriksz, T. R. %A Teijink, J. A. W. %A Odink, H. F. %A Smet, A. A. E. A. De %A Vroegindeweij, D. %A van Loenhout, R. M. M. %A Rutten, M. J. %A Hamming, J. F. %A Lampmann, L. E. H. %A Bender, M. H. M. %A Pasmans, H. %A Vahl, A. C. %A de Vries, C. %A Mackaay, A. J. C. %A van Dortmont, L. M. C. %A van der Vliet, D. %A Kool, L. S. %A Boomsma, J. H. B. %A van Dop, H. R. %A van Otterloo, J. C. A. D. %A de Rooij, T. P. W. %A Smits, T. M. %A Yilmaz, E. N. %A van den Berg, F. G. %A Visser, M. J. T. %A van der Linden, E. %A Schurink, G. W. H. %A de Haan, M. %A Smeets, H. J. %A Stabel, P. %A van Elst, F. %A Poniewierski, J. %A Vermassen, F. E. G. %D 2004 %J New England Journal of Medicine %K AAA CLINICAL-TRIALS COMPLICATIONS COST-EFFECTIVENESS DECISION-ANALYSIS LIFE MODEL MORTALITY MULTICENTER OPEN REPAIR STENT-GRAFT SURGERY SURGICAL SURVEILLANCE TRIAL %N 16 %P 1607-1618 %T A randomized trial comparing conventional and endovascular repair of abdominal aortic aneurysms %V 351 %X BACKGROUND: Although the initial results of endovascular repair of abdominal aortic aneurysms were promising, current evidence from controlled studies does not convincingly show a reduction in 30-day mortality relative to that achieved with open repair. METHODS: We conducted a multicenter, randomized trial comparing open repair with endovascular repair in 345 patients who had received a diagnosis of abdominal aortic aneurysm of at least 5 cm in diameter and who were considered suitable candidates for both techniques. The outcome events analyzed were operative (30-day) mortality and two composite end points of operative mortality and severe complications and operative mortality and moderate or severe complications. RESULTS: The operative mortality rate was 4.6 percent in the open-repair group (8 of 174 patients; 95 percent confidence interval, 2.0 to 8.9 percent) and 1.2 percent in the endovascular-repair group (2 of 171 patients; 95 percent confidence interval, 0.1 to 4.2 percent), resulting in a risk ratio of 3.9 (95 percent confidence interval, 0.9 to 32.9). The combined rate of operative mortality and severe complications was 9.8 percent in the open-repair group (17 of 174 patients; 95 percent confidence interval, 5.8 to 15.2 percent) and 4.7 percent in the endovascular-repair group (8 of 171 patients; 95 percent confidence interval, 2.0 to 9.0 percent), resulting in a risk ratio of 2.1 (95 percent confidence interval, 0.9 to 5.4). CONCLUSIONS: On the basis of the overall results of this trial, endovascular repair is preferable to open repair in patients who have an abdominal aortic aneurysm that is at least 5 cm in diameter. Long-term follow-up is needed to determine whether this advantage is sustained

@article{Prinssen2004, abstract = {BACKGROUND: Although the initial results of endovascular repair of abdominal aortic aneurysms were promising, current evidence from controlled studies does not convincingly show a reduction in 30-day mortality relative to that achieved with open repair. METHODS: We conducted a multicenter, randomized trial comparing open repair with endovascular repair in 345 patients who had received a diagnosis of abdominal aortic aneurysm of at least 5 cm in diameter and who were considered suitable candidates for both techniques. The outcome events analyzed were operative (30-day) mortality and two composite end points of operative mortality and severe complications and operative mortality and moderate or severe complications. RESULTS: The operative mortality rate was 4.6 percent in the open-repair group (8 of 174 patients; 95 percent confidence interval, 2.0 to 8.9 percent) and 1.2 percent in the endovascular-repair group (2 of 171 patients; 95 percent confidence interval, 0.1 to 4.2 percent), resulting in a risk ratio of 3.9 (95 percent confidence interval, 0.9 to 32.9). The combined rate of operative mortality and severe complications was 9.8 percent in the open-repair group (17 of 174 patients; 95 percent confidence interval, 5.8 to 15.2 percent) and 4.7 percent in the endovascular-repair group (8 of 171 patients; 95 percent confidence interval, 2.0 to 9.0 percent), resulting in a risk ratio of 2.1 (95 percent confidence interval, 0.9 to 5.4). CONCLUSIONS: On the basis of the overall results of this trial, endovascular repair is preferable to open repair in patients who have an abdominal aortic aneurysm that is at least 5 cm in diameter. Long-term follow-up is needed to determine whether this advantage is sustained}, added-at = {2011-03-11T12:21:24.000+0100}, author = {Prinssen, M. and Verhoeven, E. L. G. and Buth, J. and Cuypers, P. W. M. and van Sambeek, M. R. H. M. and Balm, R. and Buskens, E. and Grobbee, D. E. and Blankensteijn, J. D. and Pattynama, P. M. and van Voorthuisen, A. E. and Bak, A. A. A. and Hunink, M. G. and van Engelshoven, J. M. and Jacobs, M. J. H. M. and Mol, B. A. J. M. De and van Bockel, J. H. and Reekers, J. and Tielbeek, X. and Wisselink, W. and Boekema, N. and Sikking, I. and Tielbeek, A. V. and Reekers, J. A. and Pattynama, P. and Prins, T. and van der Ham, A. C. and van der Velden, J. J. I. M. and van Sterkenburg, S. M. M. and ten Haken, G. B. and Bruijninckx, C. M. A. and van Overhagen, H. and Nolthenius, R. P. T. and Hendriksz, T. R. and Teijink, J. A. W. and Odink, H. F. and Smet, A. A. E. A. De and Vroegindeweij, D. and van Loenhout, R. M. M. and Rutten, M. J. and Hamming, J. F. and Lampmann, L. E. H. and Bender, M. H. M. and Pasmans, H. and Vahl, A. C. and de Vries, C. and Mackaay, A. J. C. and van Dortmont, L. M. C. and van der Vliet, D. and Kool, L. S. and Boomsma, J. H. B. and van Dop, H. R. and van Otterloo, J. C. A. D. and de Rooij, T. P. W. and Smits, T. M. and Yilmaz, E. N. and van den Berg, F. G. and Visser, M. J. T. and van der Linden, E. and Schurink, G. W. H. and de Haan, M. and Smeets, H. J. and Stabel, P. and van Elst, F. and Poniewierski, J. and Vermassen, F. E. G.}, biburl = {https://www.bibsonomy.org/bibtex/26a3a281a86a1745ee1c6263ea56e70d9/jmaiora}, interhash = {21919923002e38255cf74c4ce16cafb2}, intrahash = {6a3a281a86a1745ee1c6263ea56e70d9}, journal = {New England Journal of Medicine}, keywords = {AAA CLINICAL-TRIALS COMPLICATIONS COST-EFFECTIVENESS DECISION-ANALYSIS LIFE MODEL MORTALITY MULTICENTER OPEN REPAIR STENT-GRAFT SURGERY SURGICAL SURVEILLANCE TRIAL}, number = 16, pages = {1607-1618}, timestamp = {2011-03-11T12:21:27.000+0100}, title = {A randomized trial comparing conventional and endovascular repair of abdominal aortic aneurysms}, volume = 351, year = 2004 }