@article{xie2018let7c,
  abstract = {Cholangiocarcinoma (CCA) is a cancer type with high postoperative relapse rates and poor long-term survival largely due to tumor invasion, distant metastasis, and multidrug resistance. Deregulated microRNAs (miRNAs) are implicated in several cancer types including CCA. The specific roles of the miRNA let-7c in cholangiocarcinoma are not known and need to be further elucidated. In our translational study we show that microRNA let-7c expression was significantly downregulated in human cholangiocarcinoma tissues when compared to adjacent tissues of the same patient. Let-7c inhibited the tumorigenic properties of cholangiocarcinoma cells including their self-renewal capacity and sphere formation in vitro and subcutaneous cancer cell growth in vivo. Ectopic let-7c overexpression suppressed migration and invasion capacities of cholangiocarcinoma cell lines in vitro, however, promoted distant invasiveness in vivo. Furthermore, we found that let-7c regulated the aforementioned malignant biological properties, at least in part, through regulation of EZH2 protein expression and through the DVL3/β-catenin axis. The miRNA let-7c thus plays an important dual role in regulating tumorigenic and metastatic abilities of human cholangiocarcinoma through mechanisms involving EZH2 protein and the DVL3/β-catenin axis.},
  added-at = {2018-03-01T13:45:45.000+0100},
  author = {Xie, Y and Zhang, H and Guo, X J and Feng, Y C and He, R Z and Li, X and Yu, S and Zhao, Y and Shen, M and Zhu, F and Wang, X and Wang, M and Balakrishnan, A and Ott, M and Peng, F and Qin, R Y},
  biburl = {https://www.bibsonomy.org/bibtex/21e519e8751b6fb36b2b57db4dedc66b4/ott},
  editor = {Dis, Cell Death},
  interhash = {4945afa606c580baad75294ffc1dcc87},
  intrahash = {1e519e8751b6fb36b2b57db4dedc66b4},
  journal = {Cell Death & Disease},
  keywords = {Ott},
  number = 2,
  pages = 249,
  pubmedurl = {https://www.ncbi.nlm.nih.gov/pubmed/29445149},
  timestamp = {2018-03-01T13:45:45.000+0100},
  title = {Let-7c inhibits cholangiocarcinoma growth but promotes tumor cell invasion and growth at extrahepatic sites},
  volume = 9,
  year = 2018
}