Molecular sensing in the lingual mucosa and in the gastro-intestinal tract play a role in the detection of ingested harmful drugs and toxins. Therefore, genetic polymorphisms affecting the capability of initiating these responses may be critical for the subsequent efficiency of avoiding and/or eliminating possible threats to the organism. By using a tagging approach in the region of Taste Receptor 2R38 (TAS2R38) gene, we investigated all the common genetic variation of this gene region in relation to colorectal cancer risk with a case-control study in a German population (709 controls and 602 cases) and in a Czech population (623 controls and 601 cases). We found that there were no significant associations between individual SNPs of the TAS2R38 gene and colorectal cancer in the Czech or in the German population, nor in the joint analysis. However, when we analyzed the diplotypes and the phenotypes we found that the non-taster group had an increased risk of colorectal cancer in comparison to the taster group. This association was borderline significant in the Czech population, (OR = 1.28, 95\% CI 0.99-1.67; P(value) = 0.058) and statistically significant in the German population (OR = 1.36, 95\% CI 1.06-1.75; P(value) = 0.016) and in the joint analysis (OR = 1.34, 95\% CI 1.12-1.61; P(value) = 0.001). In conclusion, we found a suggestive association between the human bitter tasting phenotype and the risk of CRC in two different populations of Caucasian origin.
%0 Journal Article
%1 Carrai.2011
%A Carrai, Maura
%A Steinke, Verena
%A Vodicka, Pavel
%A Pardini, Barbara
%A Rahner, Nils
%A Holinski-Feder, Elke
%A Morak, Monika
%A Schackert, Hans K.
%A Görgens, Heike
%A Stemmler, Susanne
%A Betz, Beate
%A Kloor, Matthias
%A Engel, Christoph
%A Büttner, Reinhard
%A Naccarati, Alessio
%A Vodickova, Ludmila
%A Novotny, Jan
%A Stein, Angelika
%A Hemminki, Kari
%A Propping, Peter
%A Försti, Asta
%A Canzian, Federico
%A Barale, Roberto
%A Campa, Daniele
%D 2011
%J PloS one
%K Adult Aged Case-Control_Studies Colorectal_Neoplasms/genetics European_Continental_Ancestry_Group/genetics Female Genetic_Predisposition_to_Disease/genetics Haplotypes/genetics Humans Male Middle_Aged Phenotype Polymorphism,_Single_Nucleotide Quality_Control Receptors,_G-Protein-Coupled/genetics
%N 6
%P e20464
%T Association between TAS2R38 gene polymorphisms and colorectal cancer risk: a case-control study in two independent populations of Caucasian origin
%V 6
%X Molecular sensing in the lingual mucosa and in the gastro-intestinal tract play a role in the detection of ingested harmful drugs and toxins. Therefore, genetic polymorphisms affecting the capability of initiating these responses may be critical for the subsequent efficiency of avoiding and/or eliminating possible threats to the organism. By using a tagging approach in the region of Taste Receptor 2R38 (TAS2R38) gene, we investigated all the common genetic variation of this gene region in relation to colorectal cancer risk with a case-control study in a German population (709 controls and 602 cases) and in a Czech population (623 controls and 601 cases). We found that there were no significant associations between individual SNPs of the TAS2R38 gene and colorectal cancer in the Czech or in the German population, nor in the joint analysis. However, when we analyzed the diplotypes and the phenotypes we found that the non-taster group had an increased risk of colorectal cancer in comparison to the taster group. This association was borderline significant in the Czech population, (OR = 1.28, 95\% CI 0.99-1.67; P(value) = 0.058) and statistically significant in the German population (OR = 1.36, 95\% CI 1.06-1.75; P(value) = 0.016) and in the joint analysis (OR = 1.34, 95\% CI 1.12-1.61; P(value) = 0.001). In conclusion, we found a suggestive association between the human bitter tasting phenotype and the risk of CRC in two different populations of Caucasian origin.
@article{Carrai.2011,
abstract = {Molecular sensing in the lingual mucosa and in the gastro-intestinal tract play a role in the detection of ingested harmful drugs and toxins. Therefore, genetic polymorphisms affecting the capability of initiating these responses may be critical for the subsequent efficiency of avoiding and/or eliminating possible threats to the organism. By using a tagging approach in the region of Taste Receptor 2R38 (TAS2R38) gene, we investigated all the common genetic variation of this gene region in relation to colorectal cancer risk with a case-control study in a German population (709 controls and 602 cases) and in a Czech population (623 controls and 601 cases). We found that there were no significant associations between individual SNPs of the TAS2R38 gene and colorectal cancer in the Czech or in the German population, nor in the joint analysis. However, when we analyzed the diplotypes and the phenotypes we found that the non-taster group had an increased risk of colorectal cancer in comparison to the taster group. This association was borderline significant in the Czech population, (OR = 1.28, 95\% CI 0.99-1.67; P(value) = 0.058) and statistically significant in the German population (OR = 1.36, 95\% CI 1.06-1.75; P(value) = 0.016) and in the joint analysis (OR = 1.34, 95\% CI 1.12-1.61; P(value) = 0.001). In conclusion, we found a suggestive association between the human bitter tasting phenotype and the risk of CRC in two different populations of Caucasian origin.},
added-at = {2014-10-14T15:27:55.000+0200},
author = {Carrai, Maura and Steinke, Verena and Vodicka, Pavel and Pardini, Barbara and Rahner, Nils and Holinski-Feder, Elke and Morak, Monika and Schackert, Hans K. and Görgens, Heike and Stemmler, Susanne and Betz, Beate and Kloor, Matthias and Engel, Christoph and Büttner, Reinhard and Naccarati, Alessio and Vodickova, Ludmila and Novotny, Jan and Stein, Angelika and Hemminki, Kari and Propping, Peter and Försti, Asta and Canzian, Federico and Barale, Roberto and Campa, Daniele},
biburl = {https://www.bibsonomy.org/bibtex/224c9b6f1aaa7d60965ab7382f78e3940/drtester},
interhash = {1ae94d8f68aeff767056fb518b728d12},
intrahash = {24c9b6f1aaa7d60965ab7382f78e3940},
journal = {PloS one},
keywords = {Adult Aged Case-Control_Studies Colorectal_Neoplasms/genetics European_Continental_Ancestry_Group/genetics Female Genetic_Predisposition_to_Disease/genetics Haplotypes/genetics Humans Male Middle_Aged Phenotype Polymorphism,_Single_Nucleotide Quality_Control Receptors,_G-Protein-Coupled/genetics},
number = 6,
pages = {e20464},
timestamp = {2014-10-14T15:27:55.000+0200},
title = {Association between TAS2R38 gene polymorphisms and colorectal cancer risk: a case-control study in two independent populations of Caucasian origin},
volume = 6,
year = 2011
}