%0 Journal Article %1 Grkovic20145089 %A Grkovic, Tanja %A Abdelmohsen, Usama Ramadan %A Othman, Eman Maher %A Stopper, Helga %A Edrada-Ebel, RuAngelie %A Hentschel, Ute %A Quinn, Ronald J. %D 2014 %J Bioorganic & Medicinal Chemistry Letters %K myown %N 21 %P 5089 - 5092 %R http://dx.doi.org/10.1016/j.bmcl.2014.08.068 %T Two new antioxidant actinosporin analogues from the calcium alginate beads culture of sponge-associated Actinokineospora sp. strain \EG49\ %U http://www.sciencedirect.com/science/article/pii/S0960894X14009251 %V 24 %X Abstract Marine sponge-associated actinomycetes represent an exciting new resource for the identification of new and novel natural products . Previously, we have reported the isolation and structural elucidation of actinosporins A (1) and B (2) from Actinokineospora sp. strain \EG49\ isolated from the marine sponge Spheciospongia vagabunda. Herein, by employing different fermentation conditions on the same microorganism, we report on the isolation and antioxidant activity of structurally related metabolites, actinosporins C (3) and D (4). The antioxidant potential of actinosporins C and D was demonstrated using the ferric reducing antioxidant power (FRAP) assay. Additionally, at 1.25 μM, actinosporins C and D showed a significant antioxidant and protective capacity from the genomic damage induced by hydrogen peroxide in the human promyelocytic (HL-60) cell line.

@article{Grkovic20145089, abstract = {Abstract Marine sponge-associated actinomycetes represent an exciting new resource for the identification of new and novel natural products . Previously, we have reported the isolation and structural elucidation of actinosporins A (1) and B (2) from Actinokineospora sp. strain \{EG49\} isolated from the marine sponge Spheciospongia vagabunda. Herein, by employing different fermentation conditions on the same microorganism, we report on the isolation and antioxidant activity of structurally related metabolites, actinosporins C (3) and D (4). The antioxidant potential of actinosporins C and D was demonstrated using the ferric reducing antioxidant power (FRAP) assay. Additionally, at 1.25 μM, actinosporins C and D showed a significant antioxidant and protective capacity from the genomic damage induced by hydrogen peroxide in the human promyelocytic (HL-60) cell line. }, added-at = {2015-04-30T14:03:38.000+0200}, author = {Grkovic, Tanja and Abdelmohsen, Usama Ramadan and Othman, Eman Maher and Stopper, Helga and Edrada-Ebel, RuAngelie and Hentschel, Ute and Quinn, Ronald J.}, biburl = {https://www.bibsonomy.org/bibtex/2340167772b974760bbd131be7c4ea951/abdelmohsen}, doi = {http://dx.doi.org/10.1016/j.bmcl.2014.08.068}, interhash = {10966af081cbc4ed8a58c956580aa61a}, intrahash = {340167772b974760bbd131be7c4ea951}, issn = {0960-894X}, journal = {Bioorganic & Medicinal Chemistry Letters }, keywords = {myown}, number = 21, pages = {5089 - 5092}, timestamp = {2015-04-30T14:03:38.000+0200}, title = {Two new antioxidant actinosporin analogues from the calcium alginate beads culture of sponge-associated Actinokineospora sp. strain \{EG49\} }, url = {http://www.sciencedirect.com/science/article/pii/S0960894X14009251}, volume = 24, year = 2014 }