@article{Kallioniemi:1992,
title = {{Comparative genomic hybridization for molecular cytogenetic analysis
of solid tumors}},
author = {A. Kallioniemi and O.P. Kallioniemi and D. Sudar and D. Rutovitz and J.W. Gray and F. Waldman and D. Pinkel},
journal = {Science},
number = {5083},
pages = {818--821},
url = {http://www.sciencemag.org/cgi/content/abstract/258/5083/818},
volume = {258},
year = {1992},
abstract = {Comparative genomic hybridization produces a map of DNA sequence copy
number as a function of chromosomal location throughout the entire
genome. Differentially labeled test DNA and normal reference DNA
are hybridized simultaneously to normal chromosome spreads. The hybridization
is detected with two different fluorochromes. Regions of gain or
loss of DNA sequences, such as deletions, duplications, or amplifications,
are seen as changes in the ratio of the intensities of the two fluorochromes
along the target chromosomes. Analysis of tumor cell lines and primary
bladder tumors identified 16 different regions of amplification,
many in loci not previously known to be amplified.},
owner = {tkirsten},
keywords = {imported }
}
::