%0 Journal Article %1 besson1999dopaminergic %A Besson, A %A Privat, A M %A Eschalier, A %A Fialip, J %D 1999 %J Pharmacol Biochem Behav %K desipramine learned_helplessness new %N 3 %P 541-548 %T Dopaminergic and opioidergic mediations of tricyclic antidepressants in the learned helplessness paradigm %U http://www.ncbi.nlm.nih.gov/pubmed/10548269 %V 64 %X The roles of dopaminergic and opioid neurotransmissions in the activity of three tricyclic antidepressants endowed with different monoamine-reuptake properties desipramine (DESI), imipramine (IMI), amineptine (AMN) were examined using a behavioral model of depression in rats; the learned helplessness paradigm. In this model, exposure of rats to inescapable shocks (day 1) produced a subsequent escape deficit in a shuttle box test (days 3, 4, and 5). The escape deficit was reversed by AMN, DESI, and IMI administered twice daily for 5 days (16 and 32 mg/kg/day, p < 0.05, days 3, 4, and 5). In addition, AMN tended to enhance the motor activity of rats during the intertrial intervals, but on the first shuttle-box test only (day 3: p < 0.05, control vs AMN). Haloperidol, a preferential D2 dopamine receptor antagonist, acutely injected IP (37.5 microg/kg), suppressed the behavioral activity of DESI and IMI but not that of AMN. Naloxone, a preferential mu-opioid receptor antagonist, acutely injected IP (0.5 mg/kg), suppressed the behavioral activity of IMI but not that of DESI and AMN. It is concluded that an increased dopaminergic activity is a neurochemical effect common to the different tricyclic antidepressants (via a presynaptic mechanism for AMN and a postsynaptic mechanism for DESI and IMI), whereas an increased mu-opioid neurotransmission does not appear to be essential.

@article{besson1999dopaminergic, abstract = {The roles of dopaminergic and opioid neurotransmissions in the activity of three tricyclic antidepressants endowed with different monoamine-reuptake properties [desipramine (DESI), imipramine (IMI), amineptine (AMN)] were examined using a behavioral model of depression in rats; the learned helplessness paradigm. In this model, exposure of rats to inescapable shocks (day 1) produced a subsequent escape deficit in a shuttle box test (days 3, 4, and 5). The escape deficit was reversed by AMN, DESI, and IMI administered twice daily for 5 days (16 and 32 mg/kg/day, p < 0.05, days 3, 4, and 5). In addition, AMN tended to enhance the motor activity of rats during the intertrial intervals, but on the first shuttle-box test only (day 3: p < 0.05, control vs AMN). Haloperidol, a preferential D2 dopamine receptor antagonist, acutely injected IP (37.5 microg/kg), suppressed the behavioral activity of DESI and IMI but not that of AMN. Naloxone, a preferential mu-opioid receptor antagonist, acutely injected IP (0.5 mg/kg), suppressed the behavioral activity of IMI but not that of DESI and AMN. It is concluded that an increased dopaminergic activity is a neurochemical effect common to the different tricyclic antidepressants (via a presynaptic mechanism for AMN and a postsynaptic mechanism for DESI and IMI), whereas an increased mu-opioid neurotransmission does not appear to be essential.}, added-at = {2013-07-06T01:49:37.000+0200}, author = {Besson, A and Privat, A M and Eschalier, A and Fialip, J}, biburl = {https://www.bibsonomy.org/bibtex/23b2d103706d3aa4fa4493df166237869/kilianjay}, description = {Dopaminergic and opioidergic mediati... [Pharmacol Biochem Behav. 1999] - PubMed - NCBI}, interhash = {b449998d144f6f3723608d43b40a6c67}, intrahash = {3b2d103706d3aa4fa4493df166237869}, journal = {Pharmacol Biochem Behav}, keywords = {desipramine learned_helplessness new}, month = nov, number = 3, pages = {541-548}, pmid = {10548269}, timestamp = {2013-07-12T14:15:20.000+0200}, title = {Dopaminergic and opioidergic mediations of tricyclic antidepressants in the learned helplessness paradigm}, url = {http://www.ncbi.nlm.nih.gov/pubmed/10548269}, volume = 64, year = 1999 }