In its broadest definition, systems biology is the application of a `systems' way of thinking about and doing cell biology. By implication, this also invites us to consider a systems approach in the context of medicine and the treatment of disease. In particular, the idea that systems biology can form the basis of a personalised, predictive medicine will require that much closer attention is paid to the analytic properties of the feedback loops which will be set up by a personalised approach to healthcare. To emphasize the role that feedback theory will play in understanding personalised medicine, we use the term feedback medicine to describe the issues outlined.In these notes we consider feedback and control systems concepts applied to two important themes in medical systems biology - personalised medicine and combinatorial intervention. In particular, we formulate a feedback control interpretation for the administration of medicine, and relate them to various forms of medical treatment.
%0 Journal Article
%1 wellstead_feedback_2006
%A Wellstead, Peter
%A Middleton, Rick
%A Wolkenhauer, Olaf
%D 2006
%J q-bio/0603032
%K - Biology Methods, Organs Quantitative Rostock SBI Tissues and
%T Feedback Medicine: Control Systems Concepts in Personalised, Predictive Medicine and Combinatorial Intervention
%U http://arxiv.org/abs/q-bio/0603032
%X In its broadest definition, systems biology is the application of a `systems' way of thinking about and doing cell biology. By implication, this also invites us to consider a systems approach in the context of medicine and the treatment of disease. In particular, the idea that systems biology can form the basis of a personalised, predictive medicine will require that much closer attention is paid to the analytic properties of the feedback loops which will be set up by a personalised approach to healthcare. To emphasize the role that feedback theory will play in understanding personalised medicine, we use the term feedback medicine to describe the issues outlined.In these notes we consider feedback and control systems concepts applied to two important themes in medical systems biology - personalised medicine and combinatorial intervention. In particular, we formulate a feedback control interpretation for the administration of medicine, and relate them to various forms of medical treatment.
@article{wellstead_feedback_2006,
abstract = {In its broadest definition, systems biology is the application of a `systems' way of thinking about and doing cell biology. By implication, this also invites us to consider a systems approach in the context of medicine and the treatment of disease. In particular, the idea that systems biology can form the basis of a personalised, predictive medicine will require that much closer attention is paid to the analytic properties of the feedback loops which will be set up by a personalised approach to healthcare. To emphasize the role that feedback theory will play in understanding personalised medicine, we use the term feedback medicine to describe the issues {outlined.In} these notes we consider feedback and control systems concepts applied to two important themes in medical systems biology - personalised medicine and combinatorial intervention. In particular, we formulate a feedback control interpretation for the administration of medicine, and relate them to various forms of medical treatment.},
added-at = {2010-09-17T16:55:15.000+0200},
author = {Wellstead, Peter and Middleton, Rick and Wolkenhauer, Olaf},
biburl = {https://www.bibsonomy.org/bibtex/2403355034cdb949c45ad765d5c160527/ra1602},
interhash = {a8ee72dadcb7b50001a9dc7c83b37ffa},
intrahash = {403355034cdb949c45ad765d5c160527},
journal = {q-bio/0603032},
keywords = {- Biology Methods, Organs Quantitative Rostock SBI Tissues and},
month = mar,
shorttitle = {Feedback Medicine},
timestamp = {2010-09-17T16:55:28.000+0200},
title = {Feedback Medicine: Control Systems Concepts in Personalised, Predictive Medicine and Combinatorial Intervention},
url = {http://arxiv.org/abs/q-bio/0603032},
year = 2006
}