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A measure of human sensitivity in acute inhalation toxicity

by: Simon Schubach

In: Journal of Loss Prevention in the Process Industries, Vol. 10, Nr. 5-6 (1997) , p. 309--315.

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URL:	http://www.sciencedirect.com/science/article/B6TGH-3SNMPR9-3/2/6dd1671443f594562fd58b8b849380af
DOI:	10.1016/S0950-4230(97)00016-8

The prediction of the probability of death or injury following the inhalation of a toxic gas or vapour is used in risk analysis. The proportion of a population responding for a given endpoint e.g. lethality can be related to the received dose using a probit model. Some of the coefficients in the probit equations are based on data from animal testing. Generally, experimental test animals are bred to exhibit low variability. Animal variability in response to toxic exposures may not adequately represent human variability in response to toxic exposures to the tested chemical. It is suggested that some independently established measure of human variability be used in the formulation of the probit equation constants rather than those that arise solely from the fitting of the animal data.

BibTeX record

@article{Schubach:1997,
  abstract = {The prediction of the probability of death or injury following the
	inhalation of a toxic gas or vapour is used in risk analysis. The
	proportion of a population responding for a given endpoint (e.g.
	lethality) can be related to the received dose using a probit model.
	Some of the coefficients in the probit equations are based on data
	from animal testing. Generally, experimental test animals are bred
	to exhibit low variability. Animal variability in response to toxic
	exposures may not adequately represent human variability in response
	to toxic exposures to the tested chemical. It is suggested that some
	independently established measure of human variability be used in
	the formulation of the probit equation constants rather than those
	that arise solely from the fitting of the animal data.},
  added-at = {2010-01-05T23:12:10.000+0100},
  author = {Schubach, Simon},
  biburl = {http://www.bibsonomy.org/bibtex/241c7da4d7c8257ab901d4dfc721c53d5/sjp},
  doi = {http://dx.doi.org/10.1016/S0950-4230(97)00016-8},
  interhash = {aa10be7090c1d18ed41949391da74a42},
  intrahash = {41c7da4d7c8257ab901d4dfc721c53d5},
  issn = {0950-4230},
  journal = {Journal of Loss Prevention in the Process Industries},
  keywords = {Acute equations, human probit toxicity, variability},
  number = {5-6},
  pages = {309--315},
  timestamp = {2010-01-05T23:12:10.000+0100},
  title = {A measure of human sensitivity in acute inhalation toxicity},
  url = {http://www.sciencedirect.com/science/article/B6TGH-3SNMPR9-3/2/6dd1671443f594562fd58b8b849380af},
  volume = 10,
  year = 1997
}

Endnote record

%0 Journal Article
%1 Schubach:1997
%A Schubach, Simon
%D 1997
%J Journal of Loss Prevention in the Process Industries
%K 
%N 5-6
%P 309--315
%T A measure of human sensitivity in acute inhalation toxicity
%R http://dx.doi.org/10.1016/S0950-4230(97)00016-8
%U http://www.sciencedirect.com/science/article/B6TGH-3SNMPR9-3/2/6dd1671443f594562fd58b8b849380af
%V 10
%X The prediction of the probability of death or injury following the
	inhalation of a toxic gas or vapour is used in risk analysis. The
	proportion of a population responding for a given endpoint (e.g.
	lethality) can be related to the received dose using a probit model.
	Some of the coefficients in the probit equations are based on data
	from animal testing. Generally, experimental test animals are bred
	to exhibit low variability. Animal variability in response to toxic
	exposures may not adequately represent human variability in response
	to toxic exposures to the tested chemical. It is suggested that some
	independently established measure of human variability be used in
	the formulation of the probit equation constants rather than those
	that arise solely from the fitting of the animal data.

BibSonomy :: publication ::

A measure of human sensitivity in acute inhalation toxicity

Resources (URL, PDF, PS...)

Abstract

BibTeX record

Endnote record