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Aversive stimuli and loss in the mesocorticolimbic dopamine system

, and . Trends Cogn Sci, 17 (6): 281-286 (June 2013)
DOI: 10.1016/j.tics.2013.04.001

Abstract

There is mounting evidence that the mesolimbic dopamine system carries valuation signals not only for appetitive or gain-related stimuli, with which it is traditionally associated, but also for aversive and loss-related stimuli. Cellular-level studies demonstrate that the neuronal architecture to support aversive stimuli encoding in this system does exist. Both cellular-level and human neuroimaging research suggest the co-existence of appetitive and aversive prediction-error signals within the mesocorticolimbic system. These findings shift the view of the mesocorticolimbic system as a singular pathway for reward to a system with multiple signals across a wide range of domains that drive value-based decision making.

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Aversive stimuli and loss in the mesocortico... [Trends Cogn Sci. 2013] - PubMed - NCBI

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