%0 Journal Article %1 Gangadhar07 %A Gangadhar, Nidhi M %A Stockwell, Brent R %D 2007 %J Curr Opin Chem Biol %K Animals Antineoplastic_Agents Cell_Death Cell_Line,_Tumor Depsipeptides Genetic_Techniques Genome Humans Imidazoles Indoles Neoplasms Pharmaceutical_Preparations Phenotype Piperazines Proteins %N 1 %P 83-7 %R 10.1016/j.cbpa.2006.11.033 %T Chemical genetic approaches to probing cell death. %U http://dx.doi.org/10.1016/j.cbpa.2006.11.033 %V 11 %X Chemical genetics has arisen as a tool for the discovery of pathways and proteins in mammalian systems. This approach, comprising small-molecule screening combined with biochemical and genomic target identification methods, enables one to assess which proteins are involved in regulating a particular phenotype. Applied to cell death, this strategy can reveal novel targets and pathways regulating the demise of mammalian cells. Numerous diseases have been linked to the loss of regulation of cell death. Defining the mechanisms governing cell death in these diseases might lead to the discovery of therapeutic agents and targets and provide a richer understanding of the mortality of living systems. Recent advances include the discovery of novel small molecules regulating cell death pathways -- necrostatin and erastin -- as well as the elucidation of the mechanism of death induced in cancer cells by the cytotoxic agent Apratoxin A.

@article{Gangadhar07, abstract = {Chemical genetics has arisen as a tool for the discovery of pathways and proteins in mammalian systems. This approach, comprising small-molecule screening combined with biochemical and genomic target identification methods, enables one to assess which proteins are involved in regulating a particular phenotype. Applied to cell death, this strategy can reveal novel targets and pathways regulating the demise of mammalian cells. Numerous diseases have been linked to the loss of regulation of cell death. Defining the mechanisms governing cell death in these diseases might lead to the discovery of therapeutic agents and targets and provide a richer understanding of the mortality of living systems. Recent advances include the discovery of novel small molecules regulating cell death pathways {--} necrostatin and erastin {--} as well as the elucidation of the mechanism of death induced in cancer cells by the cytotoxic agent Apratoxin A.}, added-at = {2010-01-26T20:35:53.000+0100}, author = {Gangadhar, Nidhi M and Stockwell, Brent R}, biburl = {https://www.bibsonomy.org/bibtex/26ae2902625b2964d19bc540d21ffe7dc/denilw}, doi = {10.1016/j.cbpa.2006.11.033}, file = {article:../Cancer/Chemical genetic approaches to probing cell death.pdf:pdf}, institution = {Department of Biological Sciences, 614 Fairchild Center, New York, NY 10027, USA.}, interhash = {124b234eedcf6adb4d630320a8bb5320}, intrahash = {6ae2902625b2964d19bc540d21ffe7dc}, journal = {Curr Opin Chem Biol}, keywords = {Animals Antineoplastic_Agents Cell_Death Cell_Line,_Tumor Depsipeptides Genetic_Techniques Genome Humans Imidazoles Indoles Neoplasms Pharmaceutical_Preparations Phenotype Piperazines Proteins}, month = Feb, number = 1, owner = {denilw}, pages = {83-7}, pdf = {C:\Users\denilw\Desktop\Steven Jones Lab\Papers\Cancer\Chemical genetic approaches to probing cell death.pdf}, pii = {S1367-5931(06)00190-6}, pmid = {17174591}, timestamp = {2010-01-26T20:35:58.000+0100}, title = {Chemical genetic approaches to probing cell death.}, url = {http://dx.doi.org/10.1016/j.cbpa.2006.11.033}, volume = 11, year = 2007 }