Multiple meningioma with different grades of malignancy: case report with genetic analysis applying single-nucleotide polymorphism array and classical cytogenetics
Multiple meningiomas with synchronous tumor lesions represent only 1-9\% of all meningiomas and usually show a uniform histology. The simultaneous occurrence of different grades of malignancy in these nodules is observed in only one third of multiple meningiomas. We report a case of a sporadic multiple meningioma presenting with different histopathological grades (WHO I and II). The tumor genome of both nodules was analyzed by GTG-banding, spectral karyotyping (SKY), locus-specific FISH, and single nucleotide polymorphism array (SNP-A) karyotyping. GTG-banding and SKY revealed 25 structural and 33 numerical aberrations with a slightly increased aberration frequency in the WHO grade II nodule. We could confirm terminal deletions on chromosomes 1p ish del(1)(p36)(p58-,pter-) 16.5\% WHO grade I and 20.9\% WHO grade II, partial deletions on 22q, and/or monosomy 22 (monosomy 22 14\% WHO grade I and 34\% WHO grade II) as the most frequent aberrations in both meningioma nodules. In the meningioma WHO grade II, in addition, a de novo paracentric inversion within chromosomal band 1p36 was detectable. Furthermore, for meningiomas de novo, dicentric chromosomes 4 could be identified in both tumor nodules. We also detected previously published segmental uniparental disomy regions 1p31.1, 6q14.1, 10q21.1, and 14q23.3 in normal control DNA of the patient and in both tumor nodules. Taken together, we describe a very rare case of multiple meningioma with overlapping but also distinct genetic aberration patterns in two nodules of different WHO grades of malignancy.
%0 Journal Article
%1 Mocker.2011
%A Mocker, Kristin
%A Holland, Heidrun
%A Ahnert, Peter
%A Schober, Ralf
%A Bauer, Manfred
%A Kirsten, Holger
%A Koschny, Ronald
%A Meixensberger, Jürgen
%A Krupp, Wolfgang
%D 2011
%J Pathology, research and practice
%K Adult Chromosome_Aberrations Chromosomes,_Human,_Pair_1 Chromosomes,_Human,_Pair_14 Chromosomes,_Human,_Pair_22 Chromosomes,_Human,_Pair_4 Cytogenetics Female Humans In_Situ_Hybridization,_Fluorescence Karyotyping Meningeal_Neoplasms/diagnosis/genetics/pathology Meningioma/diagnosis/genetics/pathology Metaphase Oligonucleotide_Array_Sequence_Analysis Polymorphism,_Single_Nucleotide
%N 1
%P 67–72
%T Multiple meningioma with different grades of malignancy: case report with genetic analysis applying single-nucleotide polymorphism array and classical cytogenetics
%V 207
%X Multiple meningiomas with synchronous tumor lesions represent only 1-9\% of all meningiomas and usually show a uniform histology. The simultaneous occurrence of different grades of malignancy in these nodules is observed in only one third of multiple meningiomas. We report a case of a sporadic multiple meningioma presenting with different histopathological grades (WHO I and II). The tumor genome of both nodules was analyzed by GTG-banding, spectral karyotyping (SKY), locus-specific FISH, and single nucleotide polymorphism array (SNP-A) karyotyping. GTG-banding and SKY revealed 25 structural and 33 numerical aberrations with a slightly increased aberration frequency in the WHO grade II nodule. We could confirm terminal deletions on chromosomes 1p ish del(1)(p36)(p58-,pter-) 16.5\% WHO grade I and 20.9\% WHO grade II, partial deletions on 22q, and/or monosomy 22 (monosomy 22 14\% WHO grade I and 34\% WHO grade II) as the most frequent aberrations in both meningioma nodules. In the meningioma WHO grade II, in addition, a de novo paracentric inversion within chromosomal band 1p36 was detectable. Furthermore, for meningiomas de novo, dicentric chromosomes 4 could be identified in both tumor nodules. We also detected previously published segmental uniparental disomy regions 1p31.1, 6q14.1, 10q21.1, and 14q23.3 in normal control DNA of the patient and in both tumor nodules. Taken together, we describe a very rare case of multiple meningioma with overlapping but also distinct genetic aberration patterns in two nodules of different WHO grades of malignancy.
@article{Mocker.2011,
abstract = {Multiple meningiomas with synchronous tumor lesions represent only 1-9\% of all meningiomas and usually show a uniform histology. The simultaneous occurrence of different grades of malignancy in these nodules is observed in only one third of multiple meningiomas. We report a case of a sporadic multiple meningioma presenting with different histopathological grades (WHO I and II). The tumor genome of both nodules was analyzed by GTG-banding, spectral karyotyping (SKY), locus-specific FISH, and single nucleotide polymorphism array (SNP-A) karyotyping. GTG-banding and SKY revealed 25 structural and 33 numerical aberrations with a slightly increased aberration frequency in the WHO grade II nodule. We could confirm terminal deletions on chromosomes 1p [ish del(1)(p36)(p58-,pter-) 16.5\% WHO grade I and 20.9\% WHO grade II], partial deletions on 22q, and/or monosomy 22 (monosomy 22 14\% WHO grade I and 34\% WHO grade II) as the most frequent aberrations in both meningioma nodules. In the meningioma WHO grade II, in addition, a de novo paracentric inversion within chromosomal band 1p36 was detectable. Furthermore, for meningiomas de novo, dicentric chromosomes 4 could be identified in both tumor nodules. We also detected previously published segmental uniparental disomy regions 1p31.1, 6q14.1, 10q21.1, and 14q23.3 in normal control DNA of the patient and in both tumor nodules. Taken together, we describe a very rare case of multiple meningioma with overlapping but also distinct genetic aberration patterns in two nodules of different WHO grades of malignancy.},
added-at = {2014-10-14T15:28:07.000+0200},
author = {Mocker, Kristin and Holland, Heidrun and Ahnert, Peter and Schober, Ralf and Bauer, Manfred and Kirsten, Holger and Koschny, Ronald and Meixensberger, Jürgen and Krupp, Wolfgang},
biburl = {https://www.bibsonomy.org/bibtex/26d69f6612e5c41a002b0c90de92f3845/drtester},
interhash = {a997c7977ab5dfd02912b2f7804631c5},
intrahash = {6d69f6612e5c41a002b0c90de92f3845},
journal = {Pathology, research and practice},
keywords = {Adult Chromosome_Aberrations Chromosomes,_Human,_Pair_1 Chromosomes,_Human,_Pair_14 Chromosomes,_Human,_Pair_22 Chromosomes,_Human,_Pair_4 Cytogenetics Female Humans In_Situ_Hybridization,_Fluorescence Karyotyping Meningeal_Neoplasms/diagnosis/genetics/pathology Meningioma/diagnosis/genetics/pathology Metaphase Oligonucleotide_Array_Sequence_Analysis Polymorphism,_Single_Nucleotide},
number = 1,
pages = {67–72},
timestamp = {2014-10-14T15:28:07.000+0200},
title = {Multiple meningioma with different grades of malignancy: case report with genetic analysis applying single-nucleotide polymorphism array and classical cytogenetics},
volume = 207,
year = 2011
}