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Confirmation of region-specific patterns of gene expression in the human brain

by: Carl Ernst and Adolfo Sequeira and Tim Klempan and Neil Ernst and Jarlath ffrench Mullen and Gustavo Turecki

In: Neurogenetics , Vol. 8 , Nr. 3 , #aug# (2007) , p. 219--224.

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URL:	http://dx.doi.org/10.1007/s10048-007-0084-2

The human brain is divided and categorized in different ways, yet a molecular genetic approach to region specificity does not exist. Using data from 12 healthy control subjects across 18 brain regions, we performed a microarray analysis using boththe HG-U133AB and HG-U133 plus 2 chips for each subject to determine molecular targets showing region specificity. Using apreviously published data as our guide, we confirm SIX3, GPR6, SH3RF2, and hSyn as molecular markers of the nucleus accumbensand gamma-aminobutyric-acid A receptor alpha-6, Nik-related kinase, and eomesodermin as molecular markers of the cerebellum.

BibTeX record

@article{ernst07neuro,
  author = {Carl Ernst and Adolfo Sequeira and Tim Klempan and Neil Ernst and Jarlath ffrench Mullen and Gustavo Turecki},
  interHash = {871dea5cab0bab9f1464a147f8772f03},
  intraHash = {719b15632c8a56577b34e2bfaa5869aa},
  journal = {Neurogenetics},
  number = {3},
  pages = {219--224},
  title = {Confirmation of region-specific patterns of gene expression in the human brain},
  url = {http://dx.doi.org/10.1007/s10048-007-0084-2},
  volume = {8},
  year = {2007},
  month = {#aug#},
  abstract = {The human brain is divided and categorized in different ways, yet a molecular genetic approach to region specificity does
not exist. Using data from 12 healthy control subjects across 18 brain regions, we performed a microarray analysis using boththe HG-U133AB and HG-U133 plus 2 chips for each subject to determine molecular targets showing region specificity. Using apreviously published data as our guide, we confirm SIX3, GPR6, SH3RF2, and hSyn as molecular markers of the nucleus accumbensand gamma-aminobutyric-acid A receptor alpha-6, Nik-related kinase, and eomesodermin as molecular markers of the cerebellum.}
}

BibSonomy :: BibTeX ::

Confirmation of region-specific patterns of gene expression in the human brain

Resources (URL, PDF, PS...)

Abstract

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