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Genome-wide Analysis of Chromatin Regulation by Cocaine Reveals a Role for Sirtuins.

by: W. Renthal, A. Kumar, G. Xiao, M. Wilkinson, H. E. Covington, I. Maze, D. Sikder, A. J. Robison, Q. Laplant, D. M. Dietz, S. J. Russo, V. Vialou, S. Chakravarty, T. J. Kodadek, A. Stack, M. Kabbaj, and E. J. Nestler

In: Neuron, Vol. 62, Nr. 3 (May 2009) , p. 335--348.

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URL:	http://dx.doi.org/10.1016/j.neuron.2009.03.026
DOI:	10.1016/j.neuron.2009.03.026

Changes in gene expression contribute to the long-lasting regulation of the brain's reward circuitry seen in drug addiction; however, the specific genes regulated and the transcriptional mechanisms underlying such regulation remain poorly understood. Here, we used chromatin immunoprecipitation coupled with promoter microarray analysis to characterize genome-wide chromatin changes in the mouse nucleus accumbens, a crucial brain reward region, after repeated cocaine administration. Our findings reveal several interesting principles of gene regulation by cocaine and of the role of DeltaFosB and CREB, two prominent cocaine-induced transcription factors, in this brain region. The findings also provide comprehensive insight into the molecular pathways regulated by cocaine-including a new role for sirtuins Sirt1 and Sirt2-which are induced in the nucleus accumbens by cocaine and, in turn, dramatically enhance the behavioral effects of the drug.

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BibTeX record

@article{citeulike:4545321,
  abstract = {Changes in gene expression contribute to the long-lasting regulation of the brain's reward circuitry seen in drug addiction; however, the specific genes regulated and the transcriptional mechanisms underlying such regulation remain poorly understood. Here, we used chromatin immunoprecipitation coupled with promoter microarray analysis to characterize genome-wide chromatin changes in the mouse nucleus accumbens, a crucial brain reward region, after repeated cocaine administration. Our findings reveal several interesting principles of gene regulation by cocaine and of the role of DeltaFosB and CREB, two prominent cocaine-induced transcription factors, in this brain region. The findings also provide comprehensive insight into the molecular pathways regulated by cocaine-including a new role for sirtuins (Sirt1 and Sirt2)-which are induced in the nucleus accumbens by cocaine and, in turn, dramatically enhance the behavioral effects of the drug.},
  added-at = {2009-05-19T18:00:18.000+0200},
  author = {Renthal, W. and Kumar, A. and Xiao, G. and Wilkinson, M. and Covington, H. E. and Maze, I. and Sikder, D. and Robison, A. J. and Laplant, Q. and Dietz, D. M. and Russo, S. J. and Vialou, V. and Chakravarty, S. and Kodadek, T. J. and Stack, A. and Kabbaj, M. and Nestler, E. J.},
  biburl = {http://www.bibsonomy.org/bibtex/271d73256e17ff01ffc5696b7ee90ebe8/earthfare},
  citeulike-article-id = {4545321},
  description = {CiteULike: Everyone's library},
  doi = {10.1016/j.neuron.2009.03.026},
  interhash = {e3849192972f9f1f1c5dacbbcdf98006},
  intrahash = {71d73256e17ff01ffc5696b7ee90ebe8},
  issn = {1097-4199},
  journal = {Neuron},
  keywords = {imported},
  month = May,
  number = 3,
  pages = {335--348},
  posted-at = {2009-05-19 16:31:41},
  priority = {2},
  timestamp = {2009-05-19T18:00:18.000+0200},
  title = {Genome-wide Analysis of Chromatin Regulation by Cocaine Reveals a Role for Sirtuins.},
  url = {http://dx.doi.org/10.1016/j.neuron.2009.03.026},
  volume = 62,
  year = 2009
}

Endnote record

%0 Journal Article
%1 citeulike:4545321
%A Renthal, W.
%A Kumar, A.
%A Xiao, G.
%A Wilkinson, M.
%A Covington, H. E.
%A Maze, I.
%A Sikder, D.
%A Robison, A. J.
%A Laplant, Q.
%A Dietz, D. M.
%A Russo, S. J.
%A Vialou, V.
%A Chakravarty, S.
%A Kodadek, T. J.
%A Stack, A.
%A Kabbaj, M.
%A Nestler, E. J.
%D 2009
%J Neuron
%K 
%N 3
%P 335--348
%T Genome-wide Analysis of Chromatin Regulation by Cocaine Reveals a Role for Sirtuins.
%R 10.1016/j.neuron.2009.03.026
%U http://dx.doi.org/10.1016/j.neuron.2009.03.026
%V 62
%X Changes in gene expression contribute to the long-lasting regulation of the brain's reward circuitry seen in drug addiction; however, the specific genes regulated and the transcriptional mechanisms underlying such regulation remain poorly understood. Here, we used chromatin immunoprecipitation coupled with promoter microarray analysis to characterize genome-wide chromatin changes in the mouse nucleus accumbens, a crucial brain reward region, after repeated cocaine administration. Our findings reveal several interesting principles of gene regulation by cocaine and of the role of DeltaFosB and CREB, two prominent cocaine-induced transcription factors, in this brain region. The findings also provide comprehensive insight into the molecular pathways regulated by cocaine-including a new role for sirtuins (Sirt1 and Sirt2)-which are induced in the nucleus accumbens by cocaine and, in turn, dramatically enhance the behavioral effects of the drug.