BibSonomy :: publication :: Genes mirror geography within Europe

Genes mirror geography within Europe

J Novembre, T Johnson, K Bryc, Z Kutalik, A R Boyko, A Auton, A Indap, K S King, S Bergmann, M R Nelson, M Stephens, and C D Bustamante. Nature 456(7218):98-101 (November 2008)

@article{novembre2008europe,
  abstract = {Understanding the genetic structure of human populations is of fundamental interest to medical, forensic and anthropological sciences. Advances in high-throughput genotyping technology have markedly improved our understanding of global patterns of human genetic variation and suggest the potential to use large samples to uncover variation among closely spaced populations. Here we characterize genetic variation in a sample of 3,000 European individuals genotyped at over half a million variable DNA sites in the human genome. Despite low average levels of genetic differentiation among Europeans, we find a close correspondence between genetic and geographic distances; indeed, a geographical map of Europe arises naturally as an efficient two-dimensional summary of genetic variation in Europeans. The results emphasize that when mapping the genetic basis of a disease phenotype, spurious associations can arise if genetic structure is not properly accounted for. In addition, the results are relevant to the prospects of genetic ancestry testing; an individual's DNA can be used to infer their geographic origin with surprising accuracy-often to within a few hundred kilometres.},
  added-at = {2010-07-29T23:00:40.000+0200},
  author = {Novembre, J and Johnson, T and Bryc, K and Kutalik, Z and Boyko, A R and Auton, A and Indap, A and King, K S and Bergmann, S and Nelson, M R and Stephens, M and Bustamante, C D},
  biburl = {http://www.bibsonomy.org/bibtex/27593eff2cfc7528ae954b5ec88ba21c4/peter.ralph},
  description = {Genes mirror geography within Europe. [Nature. 2008] - PubMed result},
  doi = {10.1038/nature07331},
  interhash = {a479e6481126d25c9f38144d026e4f6b},
  intrahash = {7593eff2cfc7528ae954b5ec88ba21c4},
  journal = {Nature},
  keywords = {gene_flow human_genome spatial_structure},
  month = nov,
  number = 7218,
  pages = {98-101},
  pmid = {18758442},
  timestamp = {2010-07-29T23:00:40.000+0200},
  title = {Genes mirror geography within Europe},
  url = {http://www.ncbi.nlm.nih.gov/pubmed/18758442?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=8},
  volume = 456,
  year = 2008
}

%0 Journal Article
%1 novembre2008europe
%A Novembre, J
%A Johnson, T
%A Bryc, K
%A Kutalik, Z
%A Boyko, A R
%A Auton, A
%A Indap, A
%A King, K S
%A Bergmann, S
%A Nelson, M R
%A Stephens, M
%A Bustamante, C D
%D 2008
%J Nature
%K 
%N 7218
%P 98-101
%T Genes mirror geography within Europe
%R 10.1038/nature07331
%U http://www.ncbi.nlm.nih.gov/pubmed/18758442?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=8
%V 456
%X Understanding the genetic structure of human populations is of fundamental interest to medical, forensic and anthropological sciences. Advances in high-throughput genotyping technology have markedly improved our understanding of global patterns of human genetic variation and suggest the potential to use large samples to uncover variation among closely spaced populations. Here we characterize genetic variation in a sample of 3,000 European individuals genotyped at over half a million variable DNA sites in the human genome. Despite low average levels of genetic differentiation among Europeans, we find a close correspondence between genetic and geographic distances; indeed, a geographical map of Europe arises naturally as an efficient two-dimensional summary of genetic variation in Europeans. The results emphasize that when mapping the genetic basis of a disease phenotype, spurious associations can arise if genetic structure is not properly accounted for. In addition, the results are relevant to the prospects of genetic ancestry testing; an individual's DNA can be used to infer their geographic origin with surprising accuracy-often to within a few hundred kilometres.

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DOI:	10.1038/nature07331
URL:	http://www.ncbi.nlm.nih.gov/pubmed/18758442?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=8
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BibTeX key:	novembre2008europe

abstract

Understanding the genetic structure of human populations is of fundamental interest to medical, forensic and anthropological sciences. Advances in high-throughput genotyping technology have markedly improved our understanding of global patterns of human genetic variation and suggest the potential to use large samples to uncover variation among closely spaced populations. Here we characterize genetic variation in a sample of 3,000 European individuals genotyped at over half a million variable DNA sites in the human genome. Despite low average levels of genetic differentiation among Europeans, we find a close correspondence between genetic and geographic distances; indeed, a geographical map of Europe arises naturally as an efficient two-dimensional summary of genetic variation in Europeans. The results emphasize that when mapping the genetic basis of a disease phenotype, spurious associations can arise if genetic structure is not properly accounted for. In addition, the results are relevant to the prospects of genetic ancestry testing; an individual's DNA can be used to infer their geographic origin with surprising accuracy-often to within a few hundred kilometres.

Description

Genes mirror geography within Europe. [Nature. 2008] - PubMed result

publication post of peter.ralph

Genes mirror geography within Europe

discussion

resources (URL, PDF, ...)

abstract

Description