%0 Journal Article %1 li2008directcurrent %A Li, Lei %A El-Hayek, Youssef H. %A Liu, Baosong %A Chen, Yonghong %A Gomez, Everlyne %A Wu, Xiaohua %A Ning, Ke %A Li, Lijun %A Chang, Ning %A Zhang, Liang %A Wang, Zhengguo %A Hu, Xiang %A Wan, Qi %D 2008 %I John Wiley & Sons, Ltd. %J STEM CELLS %K efield migration npc phd stemcell %N 8 %P 2193--2200 %R 10.1634/stemcells.2007-1022 %T Direct-Current Electrical Field Guides Neuronal Stem/Progenitor Cell Migration %U http://dx.doi.org/10.1634/stemcells.2007-1022 %V 26 %X Direct-current electrical fields (EFs) promote nerve growth and axon regeneration. We report here that at physiological strengths, EFs guide the migration of neuronal stem/progenitor cells (NSPCs) toward the cathode. EF-directed NSPC migration requires activation of N-methyl-d-aspartate receptors (NMDARs), which leads to an increased physical association of Rho GTPase Rac1-associated signals to the membrane NMDARs and the intracellular actin cytoskeleton. Thus, this study identifies the EF as a directional guidance cue in controlling NSPC migration and reveals a role of the NMDAR/Rac1/actin signal transduction pathway in mediating EF-induced NSPC migration. These results suggest that as a safe physical approach in clinical application, EFs may be developed as a practical therapeutic strategy for brain repair by directing NSPC migration to the injured brain regions to replace cell loss.Disclosure of potential conflicts of interest is found at the end of this article.

@article{li2008directcurrent, abstract = {Direct-current electrical fields (EFs) promote nerve growth and axon regeneration. We report here that at physiological strengths, EFs guide the migration of neuronal stem/progenitor cells (NSPCs) toward the cathode. EF-directed NSPC migration requires activation of N-methyl-d-aspartate receptors (NMDARs), which leads to an increased physical association of Rho GTPase Rac1-associated signals to the membrane NMDARs and the intracellular actin cytoskeleton. Thus, this study identifies the EF as a directional guidance cue in controlling NSPC migration and reveals a role of the NMDAR/Rac1/actin signal transduction pathway in mediating EF-induced NSPC migration. These results suggest that as a safe physical approach in clinical application, EFs may be developed as a practical therapeutic strategy for brain repair by directing NSPC migration to the injured brain regions to replace cell loss.Disclosure of potential conflicts of interest is found at the end of this article.}, added-at = {2013-08-29T13:27:30.000+0200}, author = {Li, Lei and El-Hayek, Youssef H. and Liu, Baosong and Chen, Yonghong and Gomez, Everlyne and Wu, Xiaohua and Ning, Ke and Li, Lijun and Chang, Ning and Zhang, Liang and Wang, Zhengguo and Hu, Xiang and Wan, Qi}, biburl = {https://www.bibsonomy.org/bibtex/27e24b95fbba051389f30f9a4e305d859/bkoch}, description = {Direct-Current Electrical Field Guides Neuronal Stem/Progenitor Cell Migration - Li - 2008 - STEM CELLS - Wiley Online Library}, doi = {10.1634/stemcells.2007-1022}, interhash = {d2e92bdb8d25c124a0c21b760c59e22e}, intrahash = {7e24b95fbba051389f30f9a4e305d859}, issn = {1549-4918}, journal = {STEM CELLS}, keywords = {efield migration npc phd stemcell}, number = 8, pages = {2193--2200}, publisher = {John Wiley & Sons, Ltd.}, timestamp = {2013-09-30T10:37:27.000+0200}, title = {Direct-Current Electrical Field Guides Neuronal Stem/Progenitor Cell Migration}, url = {http://dx.doi.org/10.1634/stemcells.2007-1022}, volume = 26, year = 2008 }