@article{Feller1996,
title = {Requirement for cholinergic synaptic transmission in the propagation
of spontaneous retinal waves.},
author = {M. B. Feller and D. P. Wellis and D. Stellwagen and F. S. Werblin and C. J. Shatz},
journal = {Science},
month = {May},
number = {5265},
pages = {1182--1187},
volume = {272},
year = {1996},
abstract = {Highly correlated neural activity in the form of spontaneous waves
of action potentials is present in the developing retina weeks before
vision. Optical imaging revealed that these waves consist of spatially
restricted domains of activity that form a mosaic pattern over the
entire retinal ganglion cell layer. Whole-cell recordings indicate
that wave generation requires synaptic activation of neuronal nicotinic
acetylcholine receptors on ganglion cells. The only cholinergic cells
in these immature retinas are a uniformly distributed bistratified
population of amacrine cells, as assessed by antibodies to choline
acetyltransferase. The results indicate that the major source of
synaptic input to retinal ganglion cells is a system of cholinergic
amacrine cells, whose activity is required for wave propagation in
the developing retina.},
owner = {leinweber}, file = {Feller1996.pdf:Feller1996.pdf:PDF}, pmid = {8638165}, timestamp = {2007.05.30},
keywords = {system:unfiled }
}
::