%0 Journal Article %1 Schmidt.2008 %A Schmidt, Marcus %A Hasenclever, Dirk %A Schaeffer, Mitra %A Boehm, Daniel %A Cotarelo, Cristina %A Steiner, Eric %A Lebrecht, Antje %A Siggelkow, Wulf %A Weikel, Wolfgang %A Schiffer-Petry, Ilka %A Gebhard, Susanne %A Pilch, Henryk %A Gehrmann, Mathias %A Lehr, Hans-Anton %A Koelbl, Heinz %A Hengstler, Jan G. %A Schuler, Martin %D 2008 %J Clinical cancer research : an official journal of the American Association for Cancer Research %K Adult Aged Aged,_80_and_over Antigens,_Neoplasm/metabolism Breast_Neoplasms/metabolism/mortality/pathology Cell_Adhesion_Molecules/metabolism Drug_Delivery_Systems Female Humans Lymphatic_Metastasis Middle_Aged Neoplasms,_Hormone-Dependent Prognosis Tumor_Markers,_Biological %N 18 %P 5849–5855 %T Prognostic effect of epithelial cell adhesion molecule overexpression in untreated node-negative breast cancer %V 14 %X PURPOSE\r\nEpithelial cell adhesion molecule (Ep-CAM) recently received increased attention not only as a prognostic factor in breast cancer but also as a potential target for immunotherapy. We examined Ep-CAM expression in 402 consecutive node-negative breast cancer patients with long-term follow-up not treated in the adjuvant setting.\r\nEXPERIMENTAL DESIGN\r\nEp-CAM expression was evaluated by immunostaining. Its prognostic effect was estimated relative to overexpression/amplification of HER-2, histologic grade, tumor size, age, and hormone receptor expression.\r\nRESULTS\r\nEp-CAM status was positive in 106 (26.4\%) patients. In multivariate analysis, Ep-CAM status was associated with disease-free survival independent of age, pT stage, histologic grade, estrogen receptor (ER), progesterone receptor (PR), as well as HER2 status (P = 0.028; hazard ratio, 1.60; 95\% confidence interval, 1.05-2.44). Recently, so-called triple-negative (HER-2, ER, and PR) breast cancer has received increased attention. We noticed a similar association of Ep-CAM with disease-free survival in the triple-negative group as for the entire cohort.\r\nCONCLUSION\r\nIn this study of untreated breast cancer patients, Ep-CAM overexpression was associated with poor survival in the entire cohort and in the subgroup of triple-negative breast cancer. This suggests that Ep-CAM may be a well-suited target for specific therapies particularly in HER-2-, ER-, and PR-negative tumors.

@article{Schmidt.2008, abstract = {PURPOSE\r\nEpithelial cell adhesion molecule (Ep-CAM) recently received increased attention not only as a prognostic factor in breast cancer but also as a potential target for immunotherapy. We examined Ep-CAM expression in 402 consecutive node-negative breast cancer patients with long-term follow-up not treated in the adjuvant setting.\r\nEXPERIMENTAL DESIGN\r\nEp-CAM expression was evaluated by immunostaining. Its prognostic effect was estimated relative to overexpression/amplification of HER-2, histologic grade, tumor size, age, and hormone receptor expression.\r\nRESULTS\r\nEp-CAM status was positive in 106 (26.4\%) patients. In multivariate analysis, Ep-CAM status was associated with disease-free survival independent of age, pT stage, histologic grade, estrogen receptor (ER), progesterone receptor (PR), as well as HER2 status (P = 0.028; hazard ratio, 1.60; 95\% confidence interval, 1.05-2.44). Recently, so-called triple-negative (HER-2, ER, and PR) breast cancer has received increased attention. We noticed a similar association of Ep-CAM with disease-free survival in the triple-negative group as for the entire cohort.\r\nCONCLUSION\r\nIn this study of untreated breast cancer patients, Ep-CAM overexpression was associated with poor survival in the entire cohort and in the subgroup of triple-negative breast cancer. This suggests that Ep-CAM may be a well-suited target for specific therapies particularly in HER-2-, ER-, and PR-negative tumors.}, added-at = {2014-10-15T15:04:23.000+0200}, author = {Schmidt, Marcus and Hasenclever, Dirk and Schaeffer, Mitra and Boehm, Daniel and Cotarelo, Cristina and Steiner, Eric and Lebrecht, Antje and Siggelkow, Wulf and Weikel, Wolfgang and Schiffer-Petry, Ilka and Gebhard, Susanne and Pilch, Henryk and Gehrmann, Mathias and Lehr, Hans-Anton and Koelbl, Heinz and Hengstler, Jan G. and Schuler, Martin}, biburl = {https://www.bibsonomy.org/bibtex/27f4890d304edd4c4d16797e9fd61ffea/drtester}, interhash = {22c5c1e528fcf019f516ad9725a8eb19}, intrahash = {7f4890d304edd4c4d16797e9fd61ffea}, journal = {Clinical cancer research : an official journal of the American Association for Cancer Research}, keywords = {Adult Aged Aged,_80_and_over Antigens,_Neoplasm/metabolism Breast_Neoplasms/metabolism/mortality/pathology Cell_Adhesion_Molecules/metabolism Drug_Delivery_Systems Female Humans Lymphatic_Metastasis Middle_Aged Neoplasms,_Hormone-Dependent Prognosis Tumor_Markers,_Biological}, number = 18, pages = {5849–5855}, timestamp = {2014-10-15T15:04:23.000+0200}, title = {Prognostic effect of epithelial cell adhesion molecule overexpression in untreated node-negative breast cancer}, volume = 14, year = 2008 }