%0 Journal Article %1 ullah2014cytotoxic %A ullah, H.M. Arif %A Manzur, Tanzila %A Juhara, Fatematuj %A Zaman, Sayera %A Salauddin, Md %A Huq, Irfanul %D 2014 %E x, %K root %T CYTOTOXIC AND THROMBOLYTIC ACTIVITY OF ROOT EXTRACT OF MUSA PARADISIACA (FAMILY: MUSACEAE) %U http://innovareacademics.in/journals/index.php/ajpcr/article/view/1002 %X Objective: To evaluate for cytotoxicity and thrombolytic activity. Methods: The cytotoxic activity was investigated by using brine shrimp nauplii. The ethanol extract was prepared by dissolving them in DMSO (not more than 50 µL in 5 mL solution) with sea water (3.8% NaCl in water) using concentrations 6.25, 12.5, 25, 50, 100, 300 and 500 µg/mL. The extract was also evaluated for thrombolytic effect using clot lysis analysis at the concentration of 500µg, 800µg and 1000µg. Results:The ethanol extract of M. paradisiaca showed cytotoxic activity against brine shrimp nauplii and LC 50 value was 25 µg/ mL and thrombolytic activity was also investigated in our research that the % of clot lysis were 3.27, 7.59 and 13.04 at the concentration of 500µg, 800µg and 1000µg respectively. Conclusion:This is only a preliminary study.Further studies are necessary to evaluate the exact mechanism behind these activity.  Key Words: Musa paradisiaca; ethanol extract; brine shrimp nauplii:cytotoxic Activity; thrombolytic Activity

@article{ullah2014cytotoxic, abstract = { Objective: To evaluate for cytotoxicity and thrombolytic activity. Methods: The cytotoxic activity was investigated by using brine shrimp nauplii. The ethanol extract was prepared by dissolving them in DMSO (not more than 50 µL in 5 mL solution) with sea water (3.8% NaCl in water) using concentrations 6.25, 12.5, 25, 50, 100, 300 and 500 µg/mL. The extract was also evaluated for thrombolytic effect using clot lysis analysis at the concentration of 500µg, 800µg and 1000µg. Results:The ethanol extract of M. paradisiaca showed cytotoxic activity against brine shrimp nauplii and LC 50 value was 25 µg/ mL and thrombolytic activity was also investigated in our research that the % of clot lysis were 3.27, 7.59 and 13.04 at the concentration of 500µg, 800µg and 1000µg respectively. Conclusion:This is only a preliminary study.Further studies are necessary to evaluate the exact mechanism behind these activity.  Key Words: Musa paradisiaca; ethanol extract; brine shrimp nauplii:cytotoxic Activity; thrombolytic Activity }, added-at = {2014-04-08T13:07:32.000+0200}, author = {ullah, H.M. Arif and Manzur, Tanzila and Juhara, Fatematuj and Zaman, Sayera and Salauddin, Md and Huq, Irfanul}, biburl = {https://www.bibsonomy.org/bibtex/28396fdacb1f1eaf87061f7cb877835a7/liloubio}, description = {CYTOTOXIC AND THROMBOLYTIC ACTIVITY OF ROOT EXTRACT OF MUSA PARADISIACA (FAMILY: MUSACEAE) | Arif ullah | Asian Journal of Pharmaceutical and Clinical Research}, editor = {x}, id = {1002, http://innovareacademics.in/journals/index.php/ajpcr/article/view/1002}, interhash = {11a830d69e4bb42001da1a4d00a9902c}, intrahash = {8396fdacb1f1eaf87061f7cb877835a7}, keywords = {root}, timestamp = {2014-04-08T13:07:32.000+0200}, title = {CYTOTOXIC AND THROMBOLYTIC ACTIVITY OF ROOT EXTRACT OF MUSA PARADISIACA (FAMILY: MUSACEAE)}, type = {Text.Serial.Journal}, url = {http://innovareacademics.in/journals/index.php/ajpcr/article/view/1002}, year = 2014 }