%0 Journal Article %1 roumagnac_evolutionary_2006 %A Roumagnac, Philippe %A Weill, François-Xavier %A Dolecek, Christiane %A Baker, Stephen %A Brisse, Sylvain %A Chinh, Nguyen Tran %A Le, Thi Anh Hong %A Acosta, Camilo J %A Farrar, Jeremy %A Dougan, Gordon %A Achtman, Mark %D 2006 %J Science (New York, N.Y.) %K Adaptation, Africa, Agents, Alleles, Asia, Bacterial, Carrier Data, Drug Evolution, Fever, Fluoroquinolones, Genes, Genetic, Gyrase, Haplotypes, Humans, Molecular Multiple, Mutation, Nucleotide, Physiological, Polymorphism, Resistance, Salmonella Selection Sequence Single State, Typhoid Variation typhi, {(Genetics),} {(Genetics)} {Anti-Bacterial} {DNA} %N 5803 %P 1301--4 %R 314/5803/1301 %T Evolutionary history of Salmonella typhi %U http://www.ncbi.nlm.nih.gov/pubmed/17124322 %V 314 %X For microbial pathogens, phylogeographic differentiation seems to be relatively common. However, the neutral population structure of Salmonella enterica serovar Typhi reflects the continued existence of ubiquitous haplotypes over millennia. In contrast, clinical use of fluoroquinolones has yielded at least 15 independent gyrA mutations within a decade and stimulated clonal expansion of haplotype H58 in Asia and Africa. Yet, antibiotic-sensitive strains and haplotypes other than H58 still persist despite selection for antibiotic resistance. Neutral evolution in Typhi appears to reflect the asymptomatic carrier state, and adaptive evolution depends on the rapid transmission of phenotypic changes through acute infections.

@article{roumagnac_evolutionary_2006, abstract = {For microbial pathogens, phylogeographic differentiation seems to be relatively common. However, the neutral population structure of Salmonella enterica serovar Typhi reflects the continued existence of ubiquitous haplotypes over millennia. In contrast, clinical use of fluoroquinolones has yielded at least 15 independent {gyrA} mutations within a decade and stimulated clonal expansion of haplotype H58 in Asia and Africa. Yet, antibiotic-sensitive strains and haplotypes other than H58 still persist despite selection for antibiotic resistance. Neutral evolution in Typhi appears to reflect the asymptomatic carrier state, and adaptive evolution depends on the rapid transmission of phenotypic changes through acute infections.}, added-at = {2011-03-11T10:05:34.000+0100}, author = {Roumagnac, Philippe and Weill, {François-Xavier} and Dolecek, Christiane and Baker, Stephen and Brisse, Sylvain and Chinh, Nguyen Tran and Le, Thi Anh Hong and Acosta, Camilo J and Farrar, Jeremy and Dougan, Gordon and Achtman, Mark}, biburl = {https://www.bibsonomy.org/bibtex/28b5382b2f59fb3cb59286aaa618f9429/jelias}, doi = {314/5803/1301}, interhash = {4efbc42f6b6b6fd55becb89a933ed49d}, intrahash = {8b5382b2f59fb3cb59286aaa618f9429}, issn = {1095-9203}, journal = {Science {(New} York, {N.Y.)}}, keywords = {Adaptation, Africa, Agents, Alleles, Asia, Bacterial, Carrier Data, Drug Evolution, Fever, Fluoroquinolones, Genes, Genetic, Gyrase, Haplotypes, Humans, Molecular Multiple, Mutation, Nucleotide, Physiological, Polymorphism, Resistance, Salmonella Selection Sequence Single State, Typhoid Variation typhi, {(Genetics),} {(Genetics)} {Anti-Bacterial} {DNA}}, month = nov, note = {{PMID:} 17124322}, number = 5803, pages = {1301--4}, timestamp = {2011-03-11T10:06:19.000+0100}, title = {Evolutionary history of Salmonella typhi}, url = {http://www.ncbi.nlm.nih.gov/pubmed/17124322}, volume = 314, year = 2006 }