%0 Journal Article %1 Roux2013 %A Roux, Antoine %A Mourin, Gis??le %A Larsen, Martin %A Fastenackels, Sol??ne %A Urrutia, Alejandra %A Gorochov, Guy %A Autran, Brigitte %A Donner, Catherine %A Sidi, Daniel %A Sibony-Prat, Joyce %A Marchant, Arnaud %A Stern, Marc %A Sauce, Delphine %A Appay, Victor %D 2013 %J J Immunol %K tlymphocytes cmv facs %N 3 %P 1300--1306 %R 10.4049/jimmunol.1202940 %T Differential impact of age and cytomegalovirus infection on the ???? T cell compartment. %U http://dx.doi.org/10.4049/jimmunol.1202940 %V 191 %X ???? T cells represent a subset of unconventional T lymphocytes that are known for their reactivity against different pathogens and considered as intermediate mediators between adaptive and innate immunity. We provide in this paper further insights underlying the changes that affect the ???? T cell compartment with advanced age in humans. We show that both aging and CMV infection impact independently on the ???? T cell compartment. Most ???? T cells are significantly affected by age and present a decreased frequency in the elderly. The decline of the ???? T cell pool appears to be independent from the activity of the thymus, arguing in favor of an extrathymic site of ???? T cell production in humans. Of note, CMV infection, which is directly associated with the activation of the pool of V??2(-) ???? T cells, promotes nonetheless the inflation of this compartment throughout life. CMV seropositivity accentuates further the accumulation of highly differentiated lymphocytes in V??2(-) ???? T cell subsets with time, in contrast to V??2(+) ???? T cells, which maintain a less differentiated phenotype. This is similar to the effect of CMV on ???? T cells and suggests that ???? T cells may vary in differentiation phenotype according to distinct stimuli or pathogens.

@article{Roux2013, abstract = {???? T cells represent a subset of unconventional T lymphocytes that are known for their reactivity against different pathogens and considered as intermediate mediators between adaptive and innate immunity. We provide in this paper further insights underlying the changes that affect the ???? T cell compartment with advanced age in humans. We show that both aging and CMV infection impact independently on the ???? T cell compartment. Most ???? T cells are significantly affected by age and present a decreased frequency in the elderly. The decline of the ???? T cell pool appears to be independent from the activity of the thymus, arguing in favor of an extrathymic site of ???? T cell production in humans. Of note, CMV infection, which is directly associated with the activation of the pool of V??2(-) ???? T cells, promotes nonetheless the inflation of this compartment throughout life. CMV seropositivity accentuates further the accumulation of highly differentiated lymphocytes in V??2(-) ???? T cell subsets with time, in contrast to V??2(+) ???? T cells, which maintain a less differentiated phenotype. This is similar to the effect of CMV on ???? T cells and suggests that ???? T cells may vary in differentiation phenotype according to distinct stimuli or pathogens.}, added-at = {2014-01-11T02:20:02.000+0100}, author = {Roux, Antoine and Mourin, Gis??le and Larsen, Martin and Fastenackels, Sol??ne and Urrutia, Alejandra and Gorochov, Guy and Autran, Brigitte and Donner, Catherine and Sidi, Daniel and Sibony-Prat, Joyce and Marchant, Arnaud and Stern, Marc and Sauce, Delphine and Appay, Victor}, biburl = {https://www.bibsonomy.org/bibtex/2950a325879f8338739c25632b4ba52a9/aorchid}, description = {found differences in the Vd2 compartment of g/d cells. In the CMV+ not all subsets of g/d Vd2 were declining.}, doi = {10.4049/jimmunol.1202940}, file = {:allorejection/JImmunol.191.1300.pdf:PDF}, groups = {public}, institution = {INSERM Unit?? Mixte de Recherche S945, Infections and Immunity, Universit?? Pierre et Marie Curie-Paris 6, H??pital Piti??-Salp??tri??re, 75013 Paris, France.}, interhash = {9f4bdb858e47798cee0dca8040ad5e2b}, intrahash = {950a325879f8338739c25632b4ba52a9}, journal = {J Immunol}, keywords = {tlymphocytes cmv facs}, language = {eng}, medline-pst = {ppublish}, month = Aug, number = 3, pages = {1300--1306}, pii = {jimmunol.1202940}, pmid = {23817410}, timestamp = {2014-01-11T02:23:35.000+0100}, title = {Differential impact of age and cytomegalovirus infection on the ???? T cell compartment.}, url = {http://dx.doi.org/10.4049/jimmunol.1202940}, username = {aorchid}, volume = 191, year = 2013 }