%0 Journal Article %1 FuhrmannBenzakein.2000 %A Fuhrmann-Benzakein, E. %A Ma, M. N. %A Rubbia-Brandt, L. %A Mentha, G. %A Ruefenacht, D. %A Sappino, A. P. %A Pepper, M. S. %D 2000 %J Int.J Cancer %K 2 A Adult Aged Cytokines Endothelial Factor Factor-alpha Factors Fibroblast Growth Hepatocyte Humans Lymphokines Middle Necrosis Neoplasms Neovascularization Pathologic Prospective Reference Research Studies Time Transforming Tumor Values Vascular beta blood cells metabolism pathology response supply therapy %N 1 %P 40-45 %T Elevated levels of angiogenic cytokines in the plasma of cancer patients %U PM:10585580 %V 85 %X Although in the normal healthy organism angiogenesis is a tightly regulated process, under a variety of circumstances it may contribute to disease states. These include the growth of solid tumors, the hematogenous spread of tumor cells and the growth of metastasis. Our aim was to measure the levels of 5 angiogenic cytokines in the plasma of patients with a variety of cancers, to establish a plasmatic angiogenic profile. We prospectively obtained blood samples in citrated tubes from 40 healthy individuals and 75 patients with a variety of solid tumors. Patients who had received any form of treatment in the preceeding 6 months were excluded from the study. Plasma levels of the following 5 cytokines were determined by ELISA: vascular endothelial growth factor (VEGF), hepatocyte growth factor (HGF), basic fibroblast growth factor, transforming growth factor-beta and tumor necrosis factor-alpha. In some cases, additional samples were taken 4 and 15 days after surgical removal of the tumor.

@article{FuhrmannBenzakein.2000, abstract = {Although in the normal healthy organism angiogenesis is a tightly regulated process, under a variety of circumstances it may contribute to disease states. These include the growth of solid tumors, the hematogenous spread of tumor cells and the growth of metastasis. Our aim was to measure the levels of 5 angiogenic cytokines in the plasma of patients with a variety of cancers, to establish a plasmatic angiogenic profile. We prospectively obtained blood samples in citrated tubes from 40 healthy individuals and 75 patients with a variety of solid tumors. Patients who had received any form of treatment in the preceeding 6 months were excluded from the study. Plasma levels of the following 5 cytokines were determined by ELISA: vascular endothelial growth factor (VEGF), hepatocyte growth factor (HGF), basic fibroblast growth factor, transforming growth factor-beta and tumor necrosis factor-alpha. In some cases, additional samples were taken 4 and 15 days after surgical removal of the tumor. }, added-at = {2010-02-05T11:28:39.000+0100}, author = {Fuhrmann-Benzakein, E. and Ma, M. N. and Rubbia-Brandt, L. and Mentha, G. and Ruefenacht, D. and Sappino, A. P. and Pepper, M. S.}, biburl = {https://www.bibsonomy.org/bibtex/29ba73cc992524fc8b3a7d65f39898e9d/kanefendt}, interhash = {6ce1990d585389e503a654eec5c03971}, intrahash = {9ba73cc992524fc8b3a7d65f39898e9d}, journal = {Int.J Cancer}, keywords = {2 A Adult Aged Cytokines Endothelial Factor Factor-alpha Factors Fibroblast Growth Hepatocyte Humans Lymphokines Middle Necrosis Neoplasms Neovascularization Pathologic Prospective Reference Research Studies Time Transforming Tumor Values Vascular beta blood cells metabolism pathology response supply therapy}, number = 1, pages = {40-45}, timestamp = {2010-02-05T11:28:46.000+0100}, title = {Elevated levels of angiogenic cytokines in the plasma of cancer patients}, url = {PM:10585580}, volume = 85, year = 2000 }