%0 Journal Article %1 helen2003malespecific %A Skaletsky, Helen %A Kuroda-Kawaguchi, Tomoko %A Minx, Patrick J. %A Cordum, Holland S. %A Hillier, LaDeana %A Brown, Laura G. %A Repping, Sjoerd %A Pyntikova, Tatyana %A Ali, Johar %A Bieri, Tamberlyn %A Chinwalla, Asif %A Delehaunty, Andrew %A Delehaunty, Kim %A Du, Hui %A Fewell, Ginger %A Fulton, Lucinda %A Fulton, Robert %A Graves, Tina %A Hou, Shun-Fang %A Latrielle, Philip %A Leonard, Shawn %A Mardis, Elaine %A Maupin, Rachel %A McPherson, John %A Miner, Tracie %A Nash, William %A Nguyen, Christine %A Ozersky, Philip %A Pepin, Kymberlie %A Rock, Susan %A Rohlfing, Tracy %A Scott, Kelsi %A Schultz, Brian %A Strong, Cindy %A Tin-Wollam, Aye %A Yang, Shiaw-Pyng %A Waterston, Robert H. %A Wilson, Richard K. %A Rozen, Steve %A Page, David C. %D 2003 %J Nature %K Y_chromosome human_genome palindromic_DNA %N 6942 %P 825--837 %T The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes %U http://dx.doi.org/10.1038/nature01722 %V 423 %X The male-specific region of the Y chromosome, the MSY, differentiates the sexes and comprises 95% of the chromosome's length. Here, we report that the MSY is a mosaic of heterochromatic sequences and three classes of euchromatic sequences: X-transposed, X-degenerate and ampliconic. These classes contain all 156 known transcription units, which include 78 protein-coding genes that collectively encode 27 distinct proteins. The X-transposed sequences exhibit 99% identity to the X chromosome. The X-degenerate sequences are remnants of ancient autosomes from which the modern X and Y chromosomes evolved. The ampliconic class includes large regions (about 30% of the MSY euchromatin) where sequence pairs show greater than 99.9% identity, which is maintained by frequent gene conversion (non-reciprocal transfer). The most prominent features here are eight massive palindromes, at least six of which contain testis genes.

@article{helen2003malespecific, abstract = {The male-specific region of the Y chromosome, the MSY, differentiates the sexes and comprises 95% of the chromosome's length. Here, we report that the MSY is a mosaic of heterochromatic sequences and three classes of euchromatic sequences: X-transposed, X-degenerate and ampliconic. These classes contain all 156 known transcription units, which include 78 protein-coding genes that collectively encode 27 distinct proteins. The X-transposed sequences exhibit 99% identity to the X chromosome. The X-degenerate sequences are remnants of ancient autosomes from which the modern X and Y chromosomes evolved. The ampliconic class includes large regions (about 30% of the MSY euchromatin) where sequence pairs show greater than 99.9% identity, which is maintained by frequent gene conversion (non-reciprocal transfer). The most prominent features here are eight massive palindromes, at least six of which contain testis genes.}, added-at = {2010-01-22T19:19:24.000+0100}, author = {Skaletsky, Helen and Kuroda-Kawaguchi, Tomoko and Minx, Patrick J. and Cordum, Holland S. and Hillier, LaDeana and Brown, Laura G. and Repping, Sjoerd and Pyntikova, Tatyana and Ali, Johar and Bieri, Tamberlyn and Chinwalla, Asif and Delehaunty, Andrew and Delehaunty, Kim and Du, Hui and Fewell, Ginger and Fulton, Lucinda and Fulton, Robert and Graves, Tina and Hou, Shun-Fang and Latrielle, Philip and Leonard, Shawn and Mardis, Elaine and Maupin, Rachel and McPherson, John and Miner, Tracie and Nash, William and Nguyen, Christine and Ozersky, Philip and Pepin, Kymberlie and Rock, Susan and Rohlfing, Tracy and Scott, Kelsi and Schultz, Brian and Strong, Cindy and Tin-Wollam, Aye and Yang, Shiaw-Pyng and Waterston, Robert H. and Wilson, Richard K. and Rozen, Steve and Page, David C.}, biburl = {https://www.bibsonomy.org/bibtex/29dddeb115883da725deb3b6bb35f542b/peter.ralph}, description = {The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes : Article : Nature}, interhash = {854dd1611d8a82ce2472b9aea60bae8b}, intrahash = {9dddeb115883da725deb3b6bb35f542b}, issn = {00280836}, journal = {Nature}, keywords = {Y_chromosome human_genome palindromic_DNA}, month = {#jun#}, number = 6942, pages = {825--837}, timestamp = {2010-01-22T19:19:24.000+0100}, title = {The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes}, url = {http://dx.doi.org/10.1038/nature01722}, volume = 423, year = 2003 }