%0 Journal Article %1 Zwick.2011 %A Zwick, C. %A Hartmann, F. %A Zeynalova, Samira %A Pöschel, V. %A Nickenig, C. %A Reiser, M. %A Lengfelder, E. %A Peter, N. %A Schlimok, G. %A Schubert, J. %A Schmitz, Norbert %A Loeffler, Markus %A Pfreundschuh, Michael %D 2011 %J Annals of oncology : official journal of the European Society for Medical Oncology / ESMO %K IMISE-Publikationen %N 8 %P 1872–1877 %T Randomized comparison of pegfilgrastim day 4 versus day 2 for the prevention of chemotherapy-induced leukocytopenia %V 22 %X BACKGROUND\r\nTo study the effects of deferring pegfilgrastim until day 4 on the reduction of chemotherapy-induced leukocytopenia.\r\nPATIENTS AND METHODS\r\nPatients of age 61-80 years with aggressive lymphoma were randomly assigned to receive 6 mg pegfilgrastim on day 2 or 4 of a 2-week chemotherapy regimen (R-CHOP-14).\r\nRESULTS\r\nTwo hundred and ninety-two and 313 chemotherapy cycles were evaluable in 103 patients. Post-nadir pegfilgrastim serum levels were higher after day 4 than after day 2 application. This was associated with an attenuated leukocyte nadir after day 4 pegfilgrastim and there were fewer days with leukocytes <2 × 10(3)/mm(3) compared with day 2 pegfilgrastim. Grade 3 and 4 leukocytopenias (70\% versus 43.3\%; P < 0.001) and grade 4-only leukocytopenias (47\% versus 20.5\%; P < 0.001) were more frequent after day 2 pegfilgrastim. There were more chemotherapy cycles with grade 3 and 4 infections after day 2 than day 4 pegfilgrastim (9.4\% versus 6.0\%; P = 0.118). Interventional antibiotics were given more often after day 2 than after day 4 pegfilgrastim (30.7\% versus 21.9\% of cycles; P = 0.008). There were five deaths during leukocytopenia after day 2 and none after day 4 pegfilgrastim (P = 0.027).\r\nCONCLUSIONS\r\nAdministration of pegfilgrastim on day 4 was more effective in reducing severe leukocytopenias and resulted in fewer deaths during leukocytopenia. Pegfilgrastim should be given on day 4 to better exploit its myeloprotective potential.

@article{Zwick.2011, abstract = {BACKGROUND\r\nTo study the effects of deferring pegfilgrastim until day 4 on the reduction of chemotherapy-induced leukocytopenia.\r\nPATIENTS AND METHODS\r\nPatients of age 61-80 years with aggressive lymphoma were randomly assigned to receive 6 mg pegfilgrastim on day 2 or 4 of a 2-week chemotherapy regimen (R-CHOP-14).\r\nRESULTS\r\nTwo hundred and ninety-two and 313 chemotherapy cycles were evaluable in 103 patients. Post-nadir pegfilgrastim serum levels were higher after day 4 than after day 2 application. This was associated with an attenuated leukocyte nadir after day 4 pegfilgrastim and there were fewer days with leukocytes <2 × 10(3)/mm(3) compared with day 2 pegfilgrastim. Grade 3 and 4 leukocytopenias (70\% versus 43.3\%; P < 0.001) and grade 4-only leukocytopenias (47\% versus 20.5\%; P < 0.001) were more frequent after day 2 pegfilgrastim. There were more chemotherapy cycles with grade 3 and 4 infections after day 2 than day 4 pegfilgrastim (9.4\% versus 6.0\%; P = 0.118). Interventional antibiotics were given more often after day 2 than after day 4 pegfilgrastim (30.7\% versus 21.9\% of cycles; P = 0.008). There were five deaths during leukocytopenia after day 2 and none after day 4 pegfilgrastim (P = 0.027).\r\nCONCLUSIONS\r\nAdministration of pegfilgrastim on day 4 was more effective in reducing severe leukocytopenias and resulted in fewer deaths during leukocytopenia. Pegfilgrastim should be given on day 4 to better exploit its myeloprotective potential.}, added-at = {2014-10-14T15:28:16.000+0200}, author = {Zwick, C. and Hartmann, F. and Zeynalova, Samira and Pöschel, V. and Nickenig, C. and Reiser, M. and Lengfelder, E. and Peter, N. and Schlimok, G. and Schubert, J. and Schmitz, Norbert and Loeffler, Markus and Pfreundschuh, Michael}, biburl = {https://www.bibsonomy.org/bibtex/2a8fd59d3e076066706caa26ab28165d1/drtester}, interhash = {75b64aecccada7eacef4e901e2ef83ab}, intrahash = {a8fd59d3e076066706caa26ab28165d1}, journal = {Annals of oncology : official journal of the European Society for Medical Oncology / ESMO}, keywords = {IMISE-Publikationen}, number = 8, pages = {1872–1877}, timestamp = {2014-12-03T00:09:26.000+0100}, title = {Randomized comparison of pegfilgrastim day 4 versus day 2 for the prevention of chemotherapy-induced leukocytopenia}, volume = 22, year = 2011 }