%0 Journal Article %1 Neumann.2007 %A Neumann, Till %A Esser, Stefan %A Potthoff, Anja %A Pankuweit, Sabine %A Neumann, Anja %A Breuckmann, Frank %A Neuhaus, Katrin %A Kondratieva, Jana %A Buck, Thomas %A Müller-Tasch, Thomas %A Wachter, Rolf %A Prettin, Christiane %A Gelbrich, Götz %A Herzog, Wolfgang %A Pieske, Burkert %A Rauchhaus, Mathias %A Loeffler, Markus %A Maisch, Bernhard %A Mügge, Andreas %A Wasem, Jürgen %A Gerken, Guido %A Brockmeyer, Norbert H. %A Erbel, Raimund %D 2007 %J European journal of medical research %K IMISE-Publikationen %N 6 %P 243–248 %T Prevalence and natural history of heart failure in outpatient HIV-infected subjects: rationale and design of the HIV-HEART study %V 12 %X BACKGROUND HIV infection is a global public health issue that is frequently associated with cardiac involvement. However, myocardial dysfunction and heart failure are often clinically occult or attributed incorrectly to other non-cardiac disease processes even a heightened awareness and knowledge for these cardiac diseases in HIV-infected patients may lead to earlier detection and a reduction in morbidity and mortality. The present study evaluates the frequency and clinical course of myocardial dysfunction and heart failure in a HIV-infected population. METHODS The HIV-HEART (HIV-infection and HEART disease) study is a prospective, long-term cohort study. The study is designed and powered to define prevalence and natural history of chronic heart failure. Following a pilot-study of 105 HIV-infected subjects the HIV-HEART trial will contain 802 HIV-infected males and females with and without antiretroviral therapy in an urban population. HIV-HEART is performed by using non-invasive techniques for the quantification of exercise intolerance and ventricular dysfunction, including concentration of B-type natriretic peptide (BNP), transthoracal echocardiography and endurance testing. Patients with BNP >100 pg/ml achieve a magnetic resonance tomography of the heart for characterization of myocardial dysfunction and type of cardiomyopathy. To determine incidence and natural history of myocardial dysfunction and heart failure, a 2 year follow-up started in September 2006. CONCLUSIONS The HIV-HEART study will define the significance of myocardial dysfunction and heart failure in a HIV-infected urban population and classify appropriate methods for identifying high-risk patients, the basis for risk stratification and therapy.

@article{Neumann.2007, abstract = {BACKGROUND HIV infection is a global public health issue that is frequently associated with cardiac involvement. However, myocardial dysfunction and heart failure are often clinically occult or attributed incorrectly to other non-cardiac disease processes even a heightened awareness and knowledge for these cardiac diseases in HIV-infected patients may lead to earlier detection and a reduction in morbidity and mortality. The present study evaluates the frequency and clinical course of myocardial dysfunction and heart failure in a HIV-infected population. METHODS The HIV-HEART (HIV-infection and HEART disease) study is a prospective, long-term cohort study. The study is designed and powered to define prevalence and natural history of chronic heart failure. Following a pilot-study of 105 HIV-infected subjects the HIV-HEART trial will contain 802 HIV-infected males and females with and without antiretroviral therapy in an urban population. HIV-HEART is performed by using non-invasive techniques for the quantification of exercise intolerance and ventricular dysfunction, including concentration of B-type natriretic peptide (BNP), transthoracal echocardiography and endurance testing. Patients with BNP >100 pg/ml achieve a magnetic resonance tomography of the heart for characterization of myocardial dysfunction and type of cardiomyopathy. To determine incidence and natural history of myocardial dysfunction and heart failure, a 2 year follow-up started in September 2006. CONCLUSIONS The HIV-HEART study will define the significance of myocardial dysfunction and heart failure in a HIV-infected urban population and classify appropriate methods for identifying high-risk patients, the basis for risk stratification and therapy.}, added-at = {2014-10-15T15:04:13.000+0200}, author = {Neumann, Till and Esser, Stefan and Potthoff, Anja and Pankuweit, Sabine and Neumann, Anja and Breuckmann, Frank and Neuhaus, Katrin and Kondratieva, Jana and Buck, Thomas and Müller-Tasch, Thomas and Wachter, Rolf and Prettin, Christiane and Gelbrich, Götz and Herzog, Wolfgang and Pieske, Burkert and Rauchhaus, Mathias and Loeffler, Markus and Maisch, Bernhard and Mügge, Andreas and Wasem, Jürgen and Gerken, Guido and Brockmeyer, Norbert H. and Erbel, Raimund}, biburl = {https://www.bibsonomy.org/bibtex/2acb324b501fe5213a4c2708748a346fa/drtester}, interhash = {f377b4063aad5d6c379723cb974331d9}, intrahash = {acb324b501fe5213a4c2708748a346fa}, journal = {European journal of medical research}, keywords = {IMISE-Publikationen}, number = 6, pages = {243–248}, timestamp = {2014-12-03T00:08:57.000+0100}, title = {Prevalence and natural history of heart failure in outpatient HIV-infected subjects: rationale and design of the HIV-HEART study}, volume = 12, year = 2007 }