%0 Journal Article %1 Friedrichs.2008 %A Friedrichs, Birte %A Siegel, Sandra %A Kloess, Marita %A Barsoum, Adel %A Coggin, Joseph %A Rohrer, James %A Jakob, Ilja %A Tiemann, Markus %A Heidorn, Klaus %A Schulte, Christoph %A Kabelitz, Dieter %A Steinmann, Jörg %A Schmitz, Norbert %A Zeis, Matthias %D 2008 %J Journal of immunology (Baltimore, Md. : 1950) %K IMISE-Publikationen %N 9 %P 6374–6384 %T Humoral immune responses against the immature laminin receptor protein show prognostic significance in patients with chronic lymphocytic leukemia %V 180 %X Chronic lymphocytic leukemia (CLL) is characterized by a highly variable clinical course. The role of an autologous tumor-specific immune control contributing to the variable length of survival in CLL is poorly understood. We investigated whether humoral immunity specific for the CLL-associated Ag oncofetal Ag/immature laminin receptor (OFA/iLR) has a prognostic value in CLL. Among sera of 67 untreated patients with CLL, 23 (34.3\%) had detectable OFA/iLR Abs that were reactive for at least one specific OFA/iLR epitope. Patients with humoral responses compared with patients with nonreactive sera had a longer progression-free survival (p = 0.029). IgG subclass analyses showed a predominant IgG1 and IgG3 response. OFA/iLR Abs were capable of recognizing and selectively killing OFA/iLR-expressing CLL cells in complement-mediated and Ab-dependent cellular cytotoxicity assays. In the analysis of 11 CLL patients after allogeneic hematopoietic stem cell transplantation, 8 showed high values for OFA/iLR Abs that specifically recognized the extracellular domain of the protein, suggesting a potential role of anti-OFA/iLR-directed immune responses to the graft-vs-leukemia effect in CLL. Our data suggest that spontaneous tumor-specific humoral immune responses against OFA/iLR exist in a significant proportion of CLL patients and that superior progression-free survival in those patients could reflect autologous immune control.

@article{Friedrichs.2008, abstract = {Chronic lymphocytic leukemia (CLL) is characterized by a highly variable clinical course. The role of an autologous tumor-specific immune control contributing to the variable length of survival in CLL is poorly understood. We investigated whether humoral immunity specific for the CLL-associated Ag oncofetal Ag/immature laminin receptor (OFA/iLR) has a prognostic value in CLL. Among sera of 67 untreated patients with CLL, 23 (34.3\%) had detectable OFA/iLR Abs that were reactive for at least one specific OFA/iLR epitope. Patients with humoral responses compared with patients with nonreactive sera had a longer progression-free survival (p = 0.029). IgG subclass analyses showed a predominant IgG1 and IgG3 response. OFA/iLR Abs were capable of recognizing and selectively killing OFA/iLR-expressing CLL cells in complement-mediated and Ab-dependent cellular cytotoxicity assays. In the analysis of 11 CLL patients after allogeneic hematopoietic stem cell transplantation, 8 showed high values for OFA/iLR Abs that specifically recognized the extracellular domain of the protein, suggesting a potential role of anti-OFA/iLR-directed immune responses to the graft-vs-leukemia effect in CLL. Our data suggest that spontaneous tumor-specific humoral immune responses against OFA/iLR exist in a significant proportion of CLL patients and that superior progression-free survival in those patients could reflect autologous immune control.}, added-at = {2014-10-15T15:03:47.000+0200}, author = {Friedrichs, Birte and Siegel, Sandra and Kloess, Marita and Barsoum, Adel and Coggin, Joseph and Rohrer, James and Jakob, Ilja and Tiemann, Markus and Heidorn, Klaus and Schulte, Christoph and Kabelitz, Dieter and Steinmann, Jörg and Schmitz, Norbert and Zeis, Matthias}, biburl = {https://www.bibsonomy.org/bibtex/2b95e3f7a875db7aa29c58ba6c2674c99/drtester}, interhash = {80f6fe5f4169de7c7bc524c9aa3c541b}, intrahash = {b95e3f7a875db7aa29c58ba6c2674c99}, journal = {Journal of immunology (Baltimore, Md. : 1950)}, keywords = {IMISE-Publikationen}, number = 9, pages = {6374–6384}, timestamp = {2014-10-15T15:03:47.000+0200}, title = {Humoral immune responses against the immature laminin receptor protein show prognostic significance in patients with chronic lymphocytic leukemia}, volume = 180, year = 2008 }