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Effects of aspirin on intra-platelet vascular endothelial growth factor, angiopoietin-1, and p-selectin levels in hypertensive patients

by: S. Nadar, A. D. Blann, and G. Y. Lip
In: Am.J.Hypertens., Vol. 19, Nr. 9 (2006) , p. 970-977.
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Abstract

BACKGROUND: Although aspirin is useful in reducing platelet activation and cardiovascular events, its effects on platelet levels of angiogenic factors, such as vascular endothelial growth factor VEGF and angiopoietin-1 Ang-1, and markers of platelet activation in hypertension are unknown. The aim of this study was to study the effects of aspirin on the platelet morphology, plasma and platelet levels of VEGF sVEGF and pVEGF respectively, Ang-1 sAng-1 and pAng-1 respectively, and P-selectin sPsel and pPsel respectively in patients with well controlled hypertension. METHODS: A total of 35 aspirin-naive, hypertensive patients 29 male and six female; mean age 64 years were compared with 30 23 male, seven female, mean age 59 years normotensive control subjects. Blood was collected for plasma VEGF, P-selectin, and Ang-1 enzyme-linked immunoassay, intra-platelet levels of VEGF, Ang-1, and P-selectin, and platelet volume and mass. Research indices in hypertensive patients were s

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