%0 Journal Article %1 Ungerer1992 %A Ungerer, M. %A Obermaier-Skrobranek, B. %A Lohse, M. J. %D 1992 %J Eur J Pharmacol %K Adenosine/pharmacology Animals Chain Expression Gene Genetic Hypertension/*genetics/metabolism Messenger/*genetics Mutation Polymerase Purinergic/*genetics/metabolism RNA, Rats Reaction Regulation SHR Transcription, Wistar Receptor Mice %N 4 %P 381-2 %T Adenosine A1 receptor gene structure and regulation in normotensive and spontaneously hypertensive rats %U http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=1397063 %V 226 %X In spontaneously hypertensive rats (SHR), both the response to adenosine and the affinity of adenosine A1 receptors (A1R) are altered. We compared the coding sequences and the mRNA expression levels of A1R in SHR and normotensive Wistar rats (NWTR). Neither the nucleotide sequence nor the mRNA level of A1R are altered in SHR, so that gene mutations or an altered gene regulation of A1R cannot account for alterations in A1R function in SHR.

@article{Ungerer1992, abstract = {In spontaneously hypertensive rats (SHR), both the response to adenosine and the affinity of adenosine A1 receptors (A1R) are altered. We compared the coding sequences and the mRNA expression levels of A1R in SHR and normotensive Wistar rats (NWTR). Neither the nucleotide sequence nor the mRNA level of A1R are altered in SHR, so that gene mutations or an altered gene regulation of A1R cannot account for alterations in A1R function in SHR.}, added-at = {2010-12-14T18:12:02.000+0100}, author = {Ungerer, M. and Obermaier-Skrobranek, B. and Lohse, M. J.}, biburl = {https://www.bibsonomy.org/bibtex/2d005d048244fcf174d563715051a9685/pharmawuerz}, endnotereftype = {Journal Article}, interhash = {d0af854b75fb06b7baff7b9efc1c0645}, intrahash = {d005d048244fcf174d563715051a9685}, issn = {0014-2999 (Print) 0014-2999 (Linking)}, journal = {Eur J Pharmacol}, keywords = {Adenosine/pharmacology Animals Chain Expression Gene Genetic Hypertension/*genetics/metabolism Messenger/*genetics Mutation Polymerase Purinergic/*genetics/metabolism RNA, Rats Reaction Regulation SHR Transcription, Wistar Receptor Mice}, month = {Aug 3}, note = {Ungerer, M Obermaier-Skrobranek, B Lohse, M J Netherlands European journal of pharmacology Eur J Pharmacol. 1992 Aug 3;226(4):381-2.}, number = 4, pages = {381-2}, shorttitle = {Adenosine A1 receptor gene structure and regulation in normotensive and spontaneously hypertensive rats}, timestamp = {2010-12-14T18:22:57.000+0100}, title = {Adenosine A1 receptor gene structure and regulation in normotensive and spontaneously hypertensive rats}, url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=1397063}, volume = 226, year = 1992 }