%0 Journal Article %1 zhao_effects_1996 %A Zhao, X P %A Wang, S %A Xia, Y H %D 1996 %J Zhongguo yao li xue bao = Acta pharmacologica Sinica %K Active, Analgesics, Animals, Biological Calcitonin, Calcium Calcium, Cerebral Chloride, Female, Gray, Habenula, Injections, Male, Non-Narcotic, Pain Periaqueductal Rats, Threshold, Transport, Ventricles, Wistar %N 3 %P 218--220 %T Effects of calcitonin injected into various brain areas on pain threshold and Ca2+ in rats %V 17 %X AIM: To study the effects of calcitonin (Cal) injected into different brain areas on pain threshold. METHODS: The analgesic effects of Cal were investigated in rats by the tail-flick test. RESULTS: Cal injected into lateral cerebral ventricle (LCV) or periaqueductal gray (PAG) increased obviously the pain threshold to 49 +/- 22\% or to 68 +/- 12\% (P \textless 0.01), respectively. When PAG was blocked with lidocaine, the analgesic effect of Cal injected into LCV was lowered 41 +/- 9\%. Cal injected into habenula (Hab) decreased the pain threshold to -30 +/- 5\% (P \textless 0.01). CONCLUSION: Cal in different rat brain areas induced different effects on pain responses: analgesia or hyperalgesia, and showed that PAG played an important role in the analgesic effect induced by Cal, and the changing of pain threshold was mediated by the Ca2+ in brain.

@article{zhao_effects_1996, abstract = {{AIM}: To study the effects of calcitonin (Cal) injected into different brain areas on pain threshold. {METHODS}: The analgesic effects of Cal were investigated in rats by the tail-flick test. {RESULTS}: Cal injected into lateral cerebral ventricle ({LCV}) or periaqueductal gray ({PAG}) increased obviously the pain threshold to 49 +/- 22\% or to 68 +/- 12\% (P {\textless} 0.01), respectively. When {PAG} was blocked with lidocaine, the analgesic effect of Cal injected into {LCV} was lowered 41 +/- 9\%. Cal injected into habenula (Hab) decreased the pain threshold to -30 +/- 5\% (P {\textless} 0.01). {CONCLUSION}: Cal in different rat brain areas induced different effects on pain responses: analgesia or hyperalgesia, and showed that {PAG} played an important role in the analgesic effect induced by Cal, and the changing of pain threshold was mediated by the Ca2+ in brain.}, added-at = {2014-11-20T12:13:56.000+0100}, author = {Zhao, X P and Wang, S and Xia, Y H}, biburl = {https://www.bibsonomy.org/bibtex/2d04ce0d9b12279c845a5e8dfdbfd56c1/rlipp}, interhash = {291608b279345005f40dabd644377cd0}, intrahash = {d04ce0d9b12279c845a5e8dfdbfd56c1}, issn = {0253-9756}, journal = {Zhongguo yao li xue bao = Acta pharmacologica Sinica}, keywords = {Active, Analgesics, Animals, Biological Calcitonin, Calcium Calcium, Cerebral Chloride, Female, Gray, Habenula, Injections, Male, Non-Narcotic, Pain Periaqueductal Rats, Threshold, Transport, Ventricles, Wistar}, language = {eng}, month = may, number = 3, pages = {218--220}, pmid = {9812739}, timestamp = {2014-11-20T12:13:56.000+0100}, title = {Effects of calcitonin injected into various brain areas on pain threshold and Ca2+ in rats}, volume = 17, year = 1996 }