%0 Journal Article %1 RefWorks:2938 %A Gottlieb, J. %A Mattner, F. %A Weissbrodt, H. %A Dierich, M. %A Fuehner, T. %A Strueber, M. %A Simon, A. %A Welte, T. %D 2009 %J Resp Med %K pseudomonas bos transplantation rejection %N 5 %P 743-749 %R 10.1016/j.rmed.2008.11.015 %T Impact of graft colonization with gram-negative bacteria after lung transplantation on the development of bronchiolitis obliterans syndrome in recipients with cystic fibrosis %U http://dx.doi.org/10.1016/j.rmed.2008.11.015 %V 103 %X Bronchiolitis obliterans syndrome (BOS) represents the leading cause of late mortality after lung transplantation (LTx). Cystic fibrosis (CF) patients frequently show airway colonization with gram-negative bacteria (GNB) both before and after LTx. Graft colonization with GNB and its relevance towards BOS development were investigated in a CF population after LTx. Adult CF patients receiving LTx and surviving at least 6 months were included in this prospective observational study between 1/1/2002 and 30/6/2006 in a single center and followed until 31/3/2007. Pre- and post-LTx respiratory culture samples were compared for the presence of identical GNB. BOS-free survival was compared in colonized and non-colonized patients. Fifty-nine adult CF patients with a median age at LTx of 25.5 (18-49) years were included and had a median follow-up of 966 (128-1889) days. Seven patients (15%) demonstrated immediate eradication of GNB in lower respiratory tract samples. A further 18 patients (34%) demonstrated transient colonization. Thirty-four recipients had further positive samples after LTx. Eighteen patients (31%) developed BOS >or=stage 1, 508 (114-1167) days after LTx. Freedom of graft colonization with pseudomonads was independently associated with less frequent development of BOS (p=0.006). Persistent graft colonization with pseudomonads increases the prevalence of BOS after LTx in CF patients. A significant proportion of post-LTx CF patients demonstrates subsequent GNB eradication during later follow-up and this may have a protective role against development of BOS. Strategies to eradicate airway colonization or reduce bacterial load may prevent BOS in CF patients after LTx. %@ 1532-3064; 0954-6111

@article{RefWorks:2938, abstract = {Bronchiolitis obliterans syndrome (BOS) represents the leading cause of late mortality after lung transplantation (LTx). Cystic fibrosis (CF) patients frequently show airway colonization with gram-negative bacteria (GNB) both before and after LTx. Graft colonization with GNB and its relevance towards BOS development were investigated in a CF population after LTx. Adult CF patients receiving LTx and surviving at least 6 months were included in this prospective observational study between 1/1/2002 and 30/6/2006 in a single center and followed until 31/3/2007. Pre- and post-LTx respiratory culture samples were compared for the presence of identical GNB. BOS-free survival was compared in colonized and non-colonized patients. Fifty-nine adult CF patients with a median age at LTx of 25.5 (18-49) years were included and had a median follow-up of 966 (128-1889) days. Seven patients (15%) demonstrated immediate eradication of GNB in lower respiratory tract samples. A further 18 patients (34%) demonstrated transient colonization. Thirty-four recipients had further positive samples after LTx. Eighteen patients (31%) developed BOS >or=stage 1, 508 (114-1167) days after LTx. Freedom of graft colonization with pseudomonads was independently associated with less frequent development of BOS (p=0.006). Persistent graft colonization with pseudomonads increases the prevalence of BOS after LTx in CF patients. A significant proportion of post-LTx CF patients demonstrates subsequent GNB eradication during later follow-up and this may have a protective role against development of BOS. Strategies to eradicate airway colonization or reduce bacterial load may prevent BOS in CF patients after LTx.}, added-at = {2012-12-20T00:40:08.000+0100}, author = {Gottlieb, J. and Mattner, F. and Weissbrodt, H. and Dierich, M. and Fuehner, T. and Strueber, M. and Simon, A. and Welte, T.}, biburl = {https://www.bibsonomy.org/bibtex/2d54b13193a0ece67862080f0537e67a8/aorchid}, description = {see page 27 of notebook 00002. Good one. Pseudomonas (and some other GNR) persistent colonization predict BOS, as does AR.}, doi = {10.1016/j.rmed.2008.11.015}, file = {:allorejection/RespMed.103.743.pdf:PDF}, groups = {public}, interhash = {0d68e3dbb9534b074369609737a5f8f5}, intrahash = {d54b13193a0ece67862080f0537e67a8}, isbn = {1532-3064; 0954-6111}, journal = {Resp Med}, keywords = {pseudomonas bos transplantation rejection}, language = {eng}, month = May, note = {JID: 8908438; 2008/06/02 [received]; 2008/08/21 [revised]; 2008/11/18 [accepted]; 2008/12/30 [aheadofprint]; ppublish}, number = 5, pages = {743-749}, timestamp = {2012-12-20T00:40:08.000+0100}, title = {Impact of graft colonization with gram-negative bacteria after lung transplantation on the development of bronchiolitis obliterans syndrome in recipients with cystic fibrosis}, url = {http://dx.doi.org/10.1016/j.rmed.2008.11.015}, username = {aorchid}, volume = 103, year = 2009 }