Abstract
Much work has been published on the cis-regulatory elements that affect
gene function locally, as well as on the biochemistry of the transcription
factors and chromatin- and histone-modifying complexes that influence
gene expression. However, surprisingly little information is available
about how these components are organized within the three-dimensional
space of the nucleus. Technological advances are now helping to identify
the spatial relationships and interactions of genes and regulatory
elements in the nucleus and are revealing an unexpectedly extensive
network of communication within and between chromosomes. A crucial
unresolved issue is the extent to which this organization affects
gene function, rather than just reflecting it.
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