Acquired metallo-beta-lactamases (MBLs) can confer broad-spectrum beta-lactam resistance (including carbapenems) not reversible by conventional beta-lactamase inhibitors and are emerging resistance determinants of remarkable clinical importance. In 2001, multidrug-resistant Pseudomonas aeruginosa carrying bla(VIM) MBL genes were found to be widespread (approximately 20\% of all P. aeruginosa isolates and 70\% of the carbapenem-resistant isolates) at Trieste University Hospital. Clonal diversity and heterogeneity of resistance determinants (either bla(VIM-1)-like or bla(VIM-2)-like) were detected among MBL producers. This evidence is the first that acquired MBLs can rapidly emerge and establish a condition of endemicity in certain epidemiologic settings.
%0 Journal Article
%1 lagatolla_endemic_2004
%A Lagatolla, Cristina
%A Tonin, Enrico A
%A Monti-Bragadin, Carlo
%A Dolzani, Lucilla
%A Gombac, Francesca
%A Bearzi, Claudia
%A Edalucci, Elisabetta
%A Gionechetti, Fabrizia
%A Rossolini, Gian Maria
%D 2004
%J Emerging Infectious Diseases
%K Amplified Carbapenems, Drug Europe, Genotype, Humans, Polymorphic Pseudomonas Random Resistance, Technique aeruginosa, {DNA} {beta-Lactam}
%N 3
%P 535--8
%T Endemic carbapenem-resistant Pseudomonas aeruginosa with acquired metallo-beta-lactamase determinants in European hospital
%U http://www.ncbi.nlm.nih.gov/pubmed/15109432
%V 10
%X Acquired metallo-beta-lactamases (MBLs) can confer broad-spectrum beta-lactam resistance (including carbapenems) not reversible by conventional beta-lactamase inhibitors and are emerging resistance determinants of remarkable clinical importance. In 2001, multidrug-resistant Pseudomonas aeruginosa carrying bla(VIM) MBL genes were found to be widespread (approximately 20\% of all P. aeruginosa isolates and 70\% of the carbapenem-resistant isolates) at Trieste University Hospital. Clonal diversity and heterogeneity of resistance determinants (either bla(VIM-1)-like or bla(VIM-2)-like) were detected among MBL producers. This evidence is the first that acquired MBLs can rapidly emerge and establish a condition of endemicity in certain epidemiologic settings.
@article{lagatolla_endemic_2004,
abstract = {Acquired metallo-beta-lactamases {(MBLs)} can confer broad-spectrum beta-lactam resistance (including carbapenems) not reversible by conventional beta-lactamase inhibitors and are emerging resistance determinants of remarkable clinical importance. In 2001, multidrug-resistant Pseudomonas aeruginosa carrying {bla(VIM)} {MBL} genes were found to be widespread (approximately 20\% of all P. aeruginosa isolates and 70\% of the carbapenem-resistant isolates) at Trieste University Hospital. Clonal diversity and heterogeneity of resistance determinants (either {bla(VIM-1)-like} or {bla(VIM-2)-like)} were detected among {MBL} producers. This evidence is the first that acquired {MBLs} can rapidly emerge and establish a condition of endemicity in certain epidemiologic settings.},
added-at = {2011-03-11T10:05:34.000+0100},
author = {Lagatolla, Cristina and Tonin, Enrico A and {Monti-Bragadin}, Carlo and Dolzani, Lucilla and Gombac, Francesca and Bearzi, Claudia and Edalucci, Elisabetta and Gionechetti, Fabrizia and Rossolini, Gian Maria},
biburl = {https://www.bibsonomy.org/bibtex/2e317957137ce57eb7ebaf2578faf06f7/jelias},
interhash = {dfadfab0920908f4f056f2d514895adc},
intrahash = {e317957137ce57eb7ebaf2578faf06f7},
issn = {1080-6040},
journal = {Emerging Infectious Diseases},
keywords = {Amplified Carbapenems, Drug Europe, Genotype, Humans, Polymorphic Pseudomonas Random Resistance, Technique aeruginosa, {DNA} {beta-Lactam}},
month = mar,
note = {{PMID:} 15109432},
number = 3,
pages = {535--8},
timestamp = {2011-03-11T10:06:35.000+0100},
title = {Endemic carbapenem-resistant Pseudomonas aeruginosa with acquired metallo-beta-lactamase determinants in European hospital},
url = {http://www.ncbi.nlm.nih.gov/pubmed/15109432},
volume = 10,
year = 2004
}