%0 Journal Article %1 Rebbeck.2009 %A Rebbeck, Timothy R. %A Antoniou, Antonis C. %A Llopis, Trinidad Caldes %A Nevanlinna, Heli %A Aittomäki, Kristiina %A Simard, Jacques %A Spurdle, Amanda B. %A Couch, Fergus J. %A Pereira, Lutecia H Mateus, %A Greene, Mark H. %A Andrulis, Irene L. %A Pasche, Boris %A Kaklamani, Virginia %A Hamann, Ute %A Szabo, Csilla %A Peock, Susan %A Cook, Margaret %A Harrington, Patricia A. %A Donaldson, Alan %A Male, Allison M. %A Gardiner, Carol Anne %A Gregory, Helen %A Side, Lucy E. %A Robinson, Anne C. %A Emmerson, Louise %A Ellis, Ian %A Peyrat, Jean-Philippe %A Fournier, Joëlle %A Vennin, Philippe %A Adenis, Claude %A Muller, Danièle %A Fricker, Jean-Pierre %A Longy, Michel %A Sinilnikova, Olga M. %A Stoppa-Lyonnet, Dominique %A Schmutzler, Rita K. %A Versmold, Beatrix %A Engel, Christoph %A Meindl, Alfons %A Kast, Karin %A Schaefer, Dieter %A Froster, Ursula G. %A Chenevix-Trench, Georgia %A Easton, Douglas F. %D 2009 %J Breast cancer research and treatment %K Adult Alleles Breast_Neoplasms/diagnosis/genetics Cohort_Studies Female Genes,_BRCA1 Genes,_BRCA2 Genetic_Predisposition_to_Disease Genotype Heterozygote Humans Mutation Risk Transforming_Growth_Factor_beta/genetics/physiology %N 1 %P 185–192 %T No association of TGFB1 L10P genotypes and breast cancer risk in BRCA1 and BRCA2 mutation carriers: a multi-center cohort study %V 115 %X BACKGROUND\r\nThe transforming growth factor beta-1 gene (TGFB1) is a plausible candidate for breast cancer susceptibility. The L10P variant of TGFB1 is associated with higher circulating levels and secretion of TGF-beta, and recent large-scale studies suggest strongly that this variant is associated with breast cancer risk in the general population.\r\nMETHODS\r\nTo evaluate whether TGFB1 L10P also modifies the risk of breast cancer in BRCA1 or BRCA2 mutation carriers, we undertook a multi-center study of 3,442 BRCA1 and 2,095 BRCA2 mutation carriers.\r\nRESULTS\r\nWe found no evidence of association between TGFB1 L10P and breast cancer risk in either BRCA1 or BRCA2 mutation carriers. The per-allele HR for the L10P variant was 1.01 (95\%CI: 0.92-1.11) in BRCA1 carriers and 0.92 (95\%CI: 0.81-1.04) in BRCA2 mutation carriers.\r\nCONCLUSIONS\r\nThese results do not support the hypothesis that TGFB1 L10P genotypes modify the risk of breast cancer in BRCA1 or BRCA2 mutation carriers.

@article{Rebbeck.2009, abstract = {BACKGROUND\r\nThe transforming growth factor beta-1 gene (TGFB1) is a plausible candidate for breast cancer susceptibility. The L10P variant of TGFB1 is associated with higher circulating levels and secretion of TGF-beta, and recent large-scale studies suggest strongly that this variant is associated with breast cancer risk in the general population.\r\nMETHODS\r\nTo evaluate whether TGFB1 L10P also modifies the risk of breast cancer in BRCA1 or BRCA2 mutation carriers, we undertook a multi-center study of 3,442 BRCA1 and 2,095 BRCA2 mutation carriers.\r\nRESULTS\r\nWe found no evidence of association between TGFB1 L10P and breast cancer risk in either BRCA1 or BRCA2 mutation carriers. The per-allele HR for the L10P variant was 1.01 (95\%CI: 0.92-1.11) in BRCA1 carriers and 0.92 (95\%CI: 0.81-1.04) in BRCA2 mutation carriers.\r\nCONCLUSIONS\r\nThese results do not support the hypothesis that TGFB1 L10P genotypes modify the risk of breast cancer in BRCA1 or BRCA2 mutation carriers.}, added-at = {2014-10-15T15:04:18.000+0200}, author = {Rebbeck, Timothy R. and Antoniou, Antonis C. and Llopis, Trinidad Caldes and Nevanlinna, Heli and Aittomäki, Kristiina and Simard, Jacques and Spurdle, Amanda B. and Couch, Fergus J. and {Pereira, Lutecia H Mateus} and Greene, Mark H. and Andrulis, Irene L. and Pasche, Boris and Kaklamani, Virginia and Hamann, Ute and Szabo, Csilla and Peock, Susan and Cook, Margaret and Harrington, Patricia A. and Donaldson, Alan and Male, Allison M. and Gardiner, Carol Anne and Gregory, Helen and Side, Lucy E. and Robinson, Anne C. and Emmerson, Louise and Ellis, Ian and Peyrat, Jean-Philippe and Fournier, Joëlle and Vennin, Philippe and Adenis, Claude and Muller, Danièle and Fricker, Jean-Pierre and Longy, Michel and Sinilnikova, Olga M. and Stoppa-Lyonnet, Dominique and Schmutzler, Rita K. and Versmold, Beatrix and Engel, Christoph and Meindl, Alfons and Kast, Karin and Schaefer, Dieter and Froster, Ursula G. and Chenevix-Trench, Georgia and Easton, Douglas F.}, biburl = {https://www.bibsonomy.org/bibtex/21d5f352a0753b38a009fa04bf18c0302/drtester}, interhash = {2e61992a88c5ab7db27a3dc3c5202ac5}, intrahash = {1d5f352a0753b38a009fa04bf18c0302}, journal = {Breast cancer research and treatment}, keywords = {Adult Alleles Breast_Neoplasms/diagnosis/genetics Cohort_Studies Female Genes,_BRCA1 Genes,_BRCA2 Genetic_Predisposition_to_Disease Genotype Heterozygote Humans Mutation Risk Transforming_Growth_Factor_beta/genetics/physiology}, number = 1, pages = {185–192}, timestamp = {2014-10-15T15:04:18.000+0200}, title = {No association of TGFB1 L10P genotypes and breast cancer risk in BRCA1 and BRCA2 mutation carriers: a multi-center cohort study}, volume = 115, year = 2009 }